Fig. 6.

Network-based identification of miRNA-mediated pathobiological pathways for lung cancer-associated asthma. Networks illustrates the relevant miRNA sets between lung cancer and asthma. The overlapping area of two networks denotes the commonly overlapped miRNAs between lung cancer and asthma within the human protein–protein interactome network model. The subnetwork is identified by searching the meta-paths from the human protein–protein interactome network through the random walk of miRNAs between lung cancer and asthma. Four meta-path M1 (disease–miRNA–gene–gene–miRNA–disease) random walks between lung cancer and asthma validated by literature data are highlighted