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. 2019 Nov 13;9:16681. doi: 10.1038/s41598-019-52930-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of response to sleep loss phenotypes under different baseline test sessions. Histograms of the number of attentional failures observed at ~6 h awake on study day/wake period 2 (WP2), ~10 h awake on WP2, ~8 h awake on study day/wake period 3 (WP3), and ~8 h awake on constant routine (CR). Attentional failures are stratified by response phenotype at ~20 h awake (resilient, blue; intermediate, orange; vulnerable, red). These observations confirm the finding from Fig. 5A (~8 h awake WP2) that a single partition at <2 versus 2 or more attentional failures can robustly identify a subset of participants who exhibit intermediate or vulnerable phenotypes at ~20 h awake across several time points.