Table 3.
Illustration of Qalb levels within age subgroups.
|
SMA patients
≤ 15 years Mean age 12.5 (SD 2.8) range 7.0–15.0 N = 8 |
SMA patients
>15 and ≤ 40 years Mean age 27.1 (SD 7.0) range 16.0–39.0 N = 33 |
SMA patients
>40 and ≤ 60 years Mean age 48.4 (SD 4.9) range 41.0–60.0 N = 19 |
|
|---|---|---|---|
| Qalb × 103 T1 | 4.00 [2.90; 4.85] range 2.20–11.40 N = 8 |
4.14 [3.40; 6.07] range 2.60–8.08 N = 30 |
4.69 [3.90; 7.20] range 2.26–10.40 N = 19 |
| Qalb × 103 T2 | 3.90 [3.10; 5.40] range 2.70–12.20 N = 7 |
4.35 [3.60; 5.85] range 2.30–11.50 N = 32 |
5.74 [4.35; 6.85] range 3.30–15.60 N = 17 |
| Qalb × 103 T3 | 4.50 [3.50; 4.90] range 3.40–11.00 N = 7 |
4.52 [3.79; 6.44] range 2.50–11.66 N = 28 |
5.06 [4.13; 7.23] range 2.19–14.34 N = 16 |
| Qalb × 103 T4 | 4.20 [3.60; 5.10] range 3.40–11.70 N = 7 |
4.39 [3.48; 6.98] range 2.60–10.30 N = 26 |
5.92 [4.16; 8.40] range 3.20–15.00 N = 17 |
| Qalb × 103 T5 | [2.90; 4.70] range 2.80–10.80 N = 7 |
4.85 [3.63; 6.08] range 2.70–9.60 N = 22 |
5.05 [4.07; 7.20] range 2.14–11.20 N = 16 |
| Qalb × 103 T6 | [3.25; 4.25] range 3.10–4.60 N = 5 |
5.46 [4.03; 6.37] range 2.70–9.68 N = 17 |
5.57 [4.30; 7.40] range 2.42–13.14 N = 15 |
| Qalb × 103 T7 | 2.50, 4.00, 4.20, 5.10 N = 4 |
5.16 [4.21; 6.76] range 3.10–12.48 N = 14 |
4.30 [3.60; 8.20] range 2.39–9.88 N = 7 |
| Qalb × 103 T8 | 3.50, 3.60, 4.00 N = 3 |
3.80, 5.90, 7.14, 7.81 N = 4 |
4.30 N = 1 |
Median values with quartiles (in square brackets) and ranges of Qalb at treatment days T1–T8 in SMA patients undergoing treatment with nusinersen are shown. Qalb, albumin CSF/serum quotient; N, number of available samples.