TABLE 1.
Adherence gene clusters identified in the Shigella flexneri 2457T genomea
| Adherence gene | Locus tag | Annotated function/pseudogene |
|---|---|---|
| Long polar fimbriae | ||
| lpfA | S3961 | Major fimbrial subunit |
| lpfB | Chaperone/pseudogene | |
| lpfC | S4048 | Outer membrane usher |
| lpfD | Fimbrial protein/pseudogene | |
| Type 1 fimbriae | ||
| fimB | S4467 | Recombinase |
| fimE | S4466 | Tyrosine recombinase |
| fimA | S4465 | Major fimbrial subunit |
| fimI | S4464 | Pilus biosynthesis protein |
| fimC | S4463 | Chaperone |
| fimD | S4462 | Outer membrane usher/pseudogene |
| fimF | S4458 | Minor subunit |
| fimG | S4457 | Minor subunit |
| fimH | S4456 | Tip adhesin |
| Curli operon | ||
| csgG | S1104 | Assembly protein/pseudogene |
| csgF | S1105 | Assembly protein |
| csgE | S1106 | Assembly protein |
| csgD | S1107 | Transcriptional regulator |
| csgB | S1108 | Minor subunit |
| csgA | S1109 | Major subunit/pseudogene |
| csgC | S1113 | Autoagglutination assembly protein |
| S1114 | S1114 | Hypothetical (fimA homolog) |
| ybg operon | ||
| ybgD | S0591 | Fimbria-like protein (fimA homolog) |
| ybgQ | S0592 | Outer membrane protein (fimD homolog) |
| ybgP | S0593 | Chaperone (fimC homolog) |
| ybgO | S0594 | Putative fimbria-protein/pseudogene |
| ycb operon | ||
| ycbQ | S1003 | Fimbria-like adhesin/pseudogene |
| ycbS | S1006 | Outer membrane usher protein |
| S1007 | S1007 | Fimbrial protein |
| S1008 | S1008 | Fimbria-like protein |
| S1009 | S1009 | Fimbria-like protein (fimA homolog) |
| ycbF | S1010 | Putative pilus assembly chaperone |
| yeh operon | ||
| yehD | S2298 | Fimbria-like protein |
| yehC | S2297 | Chaperone/pseudogene |
| yehB | S2296 | Outer membrane usher protein |
| yehA | S2295 | Putative fimbria-protein/pseudogene |
| yra operon | ||
| yraH | S3396 | Fimbria-like adhesin/pseudogene |
| yraI | S3397 | Chaperone (fimC homolog) |
| yraJ | S3398 | Outer membrane usher/pseudogene |
| yraK | S3403 | Fimbrial protein |
| S4250-S4254 | ||
| S4250 | S4250 | Pilus assembly chaperone (papD_C homolog) |
| S4254 | S4254 | Outer membrane usher/pseudogene |
| S3342-S3341 | ||
| S3342 | S3342 | Hypothetical (fimD homolog) |
| S3341 | S3341 | Hypothetical (pilus biogenesis initiator homolog) |
| sfm operon | ||
| sfmA | S0469 | Fimbria-like protein (fimA homolog) |
| sfmC | S0470 | Chaperone |
| sfmD | Outer membrane usher/pseudogene |
a
Boldface entries provide information for the genes deleted in this study.