Table 3.
In vivo studies using PCL based scaffolds.
| S No. | Scaffold used | Experimented on | Inference | Reference |
|---|---|---|---|---|
| 1 | 10% HA reinforced PCL manufactured by solvent casting and particulate leaching method | Rabbits with calvarial bone defect MG-63 pre-osteoblast-like cells were cultured |
Increased cell proliferation and cell adhesion | Kim 2013 |
| 2 | 13%, 20%, 26% (v/v) uHA (urchin-like) dHA (MG2+-doped) 10% chloride crystals reinforced PCL by Solvent casting and Particulate leaching method | Rabbits with distal femoral condyles defects MG-63 osteoblast-like cells were cultured |
Increased Mechanical response, Higher ALP activity Higher proliferation, No inflammation. Good regeneration |
Guarino 2016 |
| 3 | PCL/HA scaffolds (60/40 w/w), realized via FDM immersed in unprocessed bone marrow blood (UBMB) taken from rabbits to create a coating and the formation of marrow clots (MC). | Rabbits with condyle and distal femur fractures | Better adhesion and proliferation and Improved osteogenic differentiation was observed. | Zheng 2017 |
| 4 | PCL/PLGA/duck beak scaffold | New Zealand White rabbits with 5 mm critical defect in diaphysis of left radius | Scaffold promotes new bone formation | Lee 2016 |
| 5 | 3D electrospun PCL/PLA blend (mass ratio: 4/1) nanofibrous scaffolds | Critical-sized cranial bone defect in mouse | strongly favorable for hMSCs osteogenic differentiation and cranial bone formation. | Yao 2017 |