Table 2.
Patient demographics, pathology, PPD recurrence, synchronous or metachronous malignancies, survival, and immunophenotypes of secondary perianal Paget's diseasea.
| Case | Age (years) | Sex | Surgical treatment | Continuous lesion or synchronous malignancy | PPD recurrence | Survival and follow-up | Cause of death | CK7 (6/13) | CK20 (10/13) | CDX2 (12/13) | GCDFP-15 (0/13) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 11 | 72 | F | APR | Rectal mucinous adenocarcinoma (synchronous, not continuous) | None | Death, 5 months | Respiratory failure | - | - | + | - |
| 12 | 71 | F | WLE+LAR | Rectal mucinous adenocarcinoma (synchronous, not continuous) | Yes, 10 years later | Alive, 11 years | None | - | + | + | - |
| 13 | 73 | M | APR | Anorectal adenocarcinoma (synchronous, not continuous) | None | Alive, 4 years | None | + | + | + | - |
| 14 | 77 | F | WLE | Anorectal carcinoma (continuous); HCC or cholangiocarcinoma (synchronous) | None | Death, 5 months | Liver tumor (suspected HCC or cholangiocarcinoma) with obstructive jaundice and septic shock | + | + | + | - |
| 15 | 77 | M | APR | Anorectal mucinous carcinoma (continuous) | None | Death, 2 years | Anorectal mucinous carcinoma with bone metastasis | + | + | + | - |
| 16 | 77 | M | APR | Anorectal adenocarcinoma (continuous) | None | Death, 4 years | Anorectal carcinoma with bone and lung metastases | F | + | + | - |
| 17 | 73 | M | APR | Anorectal adenocarcinoma (continuous) | None | Alive, 5 years | None | - | - | + | - |
| 18 | 71 | M | N/A | Anorectal adenocarcinoma (continuous) | Unknown | Unknown, lost follow-up | None | - | + | + | - |
| 19 | 50 | F | APR | Anorectal mucinous carcinoma (continuous) | None | Death, 2 years | Anorectal mucinous carcinoma with abdominal cavity, lung, and cerebellar metastases | + | + | + | - |
| 20 | 88 | M | N/A | Anorectal adenocarcinoma (continuous) | None | Death, 1 year | Congestive heart failure | - | + | + | - |
| 21 | 81 | M | APR | Anorectal adenocarcinoma (continuous) | None | Alive, 3 years | None | - | + | + | - |
| 22 | 79 | M | APR | Anorectal adenocarcinoma (continuous) | Unknown | Unknown, lost follow-up | None | + | - | - | - |
| 23 | 64 | F | WLE | Rectal adenocarcinoma (continuous) | None | Alive, 1 year | None | - | + | + | - |
aF: focally positive. PPD: perianal Paget's disease; APR: abdominal peritoneal resection; WLE: wide local excision; LAR: low anterior resection; HCC: hepatocellular carcinoma; N/A: not applicable.