. Author manuscript; available in PMC: 2020 Nov 13.

Published in final edited form as: J Am Chem Soc. 2019 Nov 1;141(45):18160–18169. doi: 10.1021/jacs.9b08894

Table 3.

Ligand Effect on Co(II)-Catalyzed Asymmetric 1,5-C–H Amination of Alkylsulfonyl Azides 3a^a


entry	catalyst	solvent	yield (%)	ee (%)
1	[Co(P4)]	benzene	10	90
2	[Co(P1)]	benzene	97	48
3	[Co(P5)]	benzene	99	69
4	[Co(P6)]	benzene	92	94
5	[Co(P6)]	chlorobenzene	95	91
6	[Co(P6)]	chloroform	95	84

Reactions were carried out at 40 °C for 18 h on 0.25 mmol scale under N₂; [3a] = 0.10 M; isolated yields enantiomeric excess determined by chiral HPLC.