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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Hypertension. 2019 Oct 21;74(6):1409–1419. doi: 10.1161/HYPERTENSIONAHA.119.13676

Figure 5. Chronic ET-1 exposure was associated with reduced vascular and endothelial uncoupling protein-1 (UCP-1) content.

Figure 5.

A) Proteomic analysis of aortas isolated from wild-type (wt, n=11) and ET-1 overexpressing transgenic (tg, n=5) mice (~ 5 months of age). Forty-seven proteins (3 upregulated, 44 downregulated) were identified as differentially expressed between the tg and wt groups. UCP-1 was identified as the most significantly downregulated protein in tg mice relative to wt controls. B) UCP-1 protein expression in cultured human aortic endothelial cell (HAEC, n=6/treatment) and C) naïve cultured mouse aortas (n=10/treatment) treated without (0nM) versus with ET-1 (10nM) for 48 hours. All data are expressed as means ± SEM. *p<0.05 vs. 0nM ET-1.