Table 1. Proteomic analysis of mouse aortas.
Aortas from male and female ET-1 overexpressing transgenic and wild-type mice were processed for proteomic analysis (11 wild-type, 5 transgenic). Forty-seven proteins were identified as differentially expressed as determined by a fold-change >1.5. Uniprot accession numbers, fold change, and p-values are listed. Fold change is relative to wild-type control (set to 1.0).
| Accession # | Description | Fold | p-value |
|---|---|---|---|
| P04202|TGFB1_MOUSE | Transforming growth factor beta-1 | 1.84 | 0.0042 |
| Q61160|FADD_MOUSE | FAS-associated death domain protein | 1.60 | 0.0003 |
| Q08879|FBLN1_MOUSE | Fibulin-1 | 1.59 | <0.0001 |
| Q9Z1Z0|USO1_MOUSE | General vesicular transport factor p115 | 0.65 | 0.0071 |
| Q9ER38|TOR3A_MOUSE | Torsin-3A | 0.63 | 0.0031 |
| Q8K4L3|SVIL_MOUSE | Supervillin | 0.62 | 0.0018 |
| Q60932|VDAC1_MOUSE | Voltage-dependent anion-selective channel protein 1 | 0.62 | 0.0048 |
| Q62348|TSN_MOUSE | Translin | 0.62 | 0.0064 |
| P11688|ITA5_MOUSE | Integrin alpha-5 | 0.60 | 0.0029 |
| Q9JLN9|MTOR_MOUSE | Serine/threonine-protein kinase mTOR | 0.59 | 0.0086 |
| Q61001|LAMA5_MOUSE | Laminin subunit alpha-5 | 0.58 | 0.00423 |
| Q923B6|STEA4_MOUSE | Metalloreductase STEAP4 | 0.57 | 0.0007 |
| P59235|NUP43_MOUSE | Nucleoporin Nup43 | 0.57 | 0.0023 |
| Q9QYA2|TOM40_MOUSE | Mitochondrial import receptor subunit TOM40 homolog | 0.56 | 0.0020 |
| Q6PDI5|ECM29_MOUSE | Proteasome adapter and scaffold protein ECM29 | 0.55 | 0.0076 |
| Q9WVC3|CAV2_MOUSE | Caveolin-2 | 0.54 | 0.0006 |
| Q9QUI0|RHOA_MOUSE | Transforming protein RhoA | 0.54 | 0.0064 |
| Q8BWM0|PGES2_MOUSE | Prostaglandin E synthase 2 | 0.54 | 0.0080 |
| Q8VDD5|MYH9_MOUSE | Myosin-9 | 0.52 | 0.0002 |
| O54890|ITB3_MOUSE | Integrin beta-3 | 0.52 | 0.0015 |
| Q8BK72|RT27_MOUSE | 28S ribosomal protein S27 mitochondrial | 0.51 | 0.0046 |
| Q99JI6|RAP1B_MOUSE | Ras-related protein Rap-1b | 0.50 | 0.0096 |
| O09118|NET1_MOUSE | Netrin-1 | 0.49 | 0.0024 |
| P68372|TBB4B_MOUSE | Tubulin beta-4B chain | 0.48 | 0.0020 |
| Q8R080|GTSE1_MOUSE | G2 and S phase-expressed protein 1 | 0.47 | 0.0057 |
| Q3U9N9|MOT10_MOUSE | Monocarboxylate transporter 10 | 0.46 | 0.0059 |
| Q9D0I9|SYRC_MOUSE | Arginine--tRNA ligase cytoplasmic | 0.45 | 0.0088 |
| Q3UV70|PDP1_MOUSE | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1 mitochondrial | 0.43 | 0.0010 |
| Q9QZI9|SERC3_MOUSE | Serine incorporator 3 | 0.43 | 0.0036 |
| P47809|MP2K4_MOUSE | Dual specificity mitogen-activated protein kinase kinase 4 | 0.43 | 0.0052 |
| Q64331|MYO6_MOUSE | Unconventional myosin-VI | 0.40 | 0.0007 |
| Q9R0H0|ACOX1_MOUSE | Peroxisomal acyl-coenzyme A oxidase 1 | 0.39 | 0.0027 |
| Q00898|A1AT5_MOUSE | Alpha-1-antitrypsin 1–5 | 0.39 | 0.0049 |
| Q9CXD6|MCUR1_MOUSE | Mitochondrial calcium uniporter regulator 1 | 0.38 | 0.0021 |
| Q9DCF9|SSRG_MOUSE | Translocon-associated protein subunit gamma | 0.38 | 0.0082 |
| Q8BSS9|LIPA2_MOUSE | Liprin-alpha-2 | 0.37 | 0.0054 |
| Q9JJU8|SH3L1_MOUSE | SH3 domain-binding glutamic acid-rich-like protein | 0.31 | <0.0001 |
| Q924L1|LTMD1_MOUSE | LETM1 domain-containing protein 1 | 0.30 | 0.0073 |
| Q9WTQ8|TIM23_MOUSE | Mitochondrial import inner membrane translocase subunit Tim23 | 0.28 | 0.0079 |
| Q5U405|TMPSD_MOUSE | Transmembrane protease serine 13 | 0.26 | 0.0040 |
| P12242|UCP1_MOUSE | Mitochondrial brown fat uncoupling protein 1 | 0.25 | 0.0040 |