Table 1.
Differential diagnosis of Nasopharyngeal papillary adenocarcinoma
| Nasopharyngeal papillary adenocarcinoma | PTC | PMA | Intestinal type adenocarcinoma-papillary variant | |
|---|---|---|---|---|
| Morphological features | Transition from overlying epithelium; Papillary and glandular architecture; Nuclear features of PTC; psammoma bodies+/ | Papillary and glandular architecture; Nuclear features of PTC; psammoma bodies± | Submucosal, separate from overlying epithelium; Multiple architectural patterns; Perineural invasion | Sinonasal location; Tubulo-papillary architecture; Mucinous/goblet cells; no nuclear features of PTC; Greater nuclear atypia |
| CK 7 | + | + | + | −/+ |
| CK 5/6 | − | − | ± | − |
| CK19 | + | + | − | + |
| CK 20 | − | − | − | + |
| TTF-1 | ± | + | − | − |
| Thyroglobulin | − | + | − | − |
| S-100 | ± | − | + | − |
| PAX8 | − | + | − | − |
| CDX-2, villin | − | − | − | + |
| Bcl2 | − | + | − | |
| Vimentin | ± | − | + | − |
| CD15 | − | + | − | −/+ |
| DOG1 | − | − | − | − |