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. 2019 Oct 21;15(12):2750–2762. doi: 10.7150/ijbs.36916

Figure 5.

Figure 5

IL-6 and IL-11 are associated with irradiation sensitivity in CRC cells. (A) SW1116 and HT29 cell growth was monitored via MTT assays for 3 consecutive days after administering rh-IL-6 and rh-IL-11. (B) HT29 and SW1116 cells were irradiated with 4 Gy, then incubated with recombinant IL-6 and IL-11 (50 µg/L and 100 µg/L) in culture medium for 3 days. Apoptosis was analyzed using flow cytometry. (C) HT29 and SW1116 cells were irradiated with 4 Gy, then incubated with nonrelevant IgG and neutralizing antibodies of IL-6 and IL-11 (50 µg/L and 100 µg/L) in culture medium for 3 days. Apoptosis was analyzed using flow cytometry. All experiments were performed in triplicate and a representative result is shown. Data are shown as the means ± S.D. *: p<0.05, **: p<0.01.