Table 2.
Preoperative analysis of overall survival
|
Univariate analysis |
Multivariate analysis |
|||
| Variable | HR (95%CI) | P value | HR (95%CI) | P value |
| Preoperative tumor size(cm) | < 0.001 | 0.012 | ||
| < 5 | Ref | Ref | ||
| ≥ 5 | 2.953 (2.227-3.915) | 1.480 (1.090-2.010) | ||
| Preoperative N stage | < 0.001 | < 0.001 | ||
| N0 | Ref | Ref | ||
| N+ | 3.219 (2.428-4.268) | 2.069 (1.536-2.787) | ||
| Preoperative T stage | < 0.001 | < 0.001 | ||
| T1-3 | Ref | Ref | ||
| T4 | 4.550 (3.132-6.609) | 2.767 (1.846-4.148) | ||
| Preoperative CA19-9 (U/mL) | < 0.001 | 0.003 | ||
| < 33.35 | Ref | Ref | ||
| ≥ 33.35 | 2.250 (1.750-2.894) | 1.569 (1.166-2.110) | ||
| ASA score | < 0.001 | < 0.001 | ||
| 1 | Ref | Ref | ||
| 2 | 1.725 (1.299-2.289) | 1.675 (1.257-2.230) | ||
| 3 | 3.805 (2.677-5.409) | 3.257 (2.271-4.670) | ||
| 3- to 6-mo weight loss | < 0.001 | 0.036 | ||
| No | Ref | Ref | ||
| Yes | 1.588 (1.231-2.049) | 1.316 (1.019-1.701) | ||
| Age (yr) | 0.008 | |||
| < 65 | Ref | |||
| ≥ 65 | 1.412 (1.095-1.821) | |||
| Gender | 0.318 | |||
| Female | Ref | |||
| Male | 1.178 (0.854-1.625) | |||
| BMI (kg/m2) | 0.473 | |||
| <25 | Ref | |||
| ≥ 25 | 0.875 (0.609-1.259) | |||
| Accompanying disease | 0.673 | |||
| No | Ref | |||
| Yes | 0.944 (0.724-1.232) | |||
| History of abdominal surgery | 0.704 | |||
| No | Ref | |||
| Yes | 1.146 (0.566-2.321) | |||
| Preoperative Charlson score | ||||
| 0 | Ref | |||
| 1-2 | 1.007 (0.768-1.322) | 0.959 | ||
| ≥ 3 | 2.202 (0.973-4.982) | 0.058 | ||
| Preoperative CEA (µg/mL) | <0.001 | |||
| < 4 | Ref | |||
| ≥ 4 | 1.673 (1.294-2.164) | |||
| HB, g/L | 0.265 | |||
| ≥ 9.0 | Ref | |||
| < 9.0 | 1.239 (0.850-1.808) | |||
| ALB, g/L | 0.014 | |||
| ≥ 35 | Ref | |||
| < 35 | 1.410 (1.072-1.854) | |||
| Fibrinogen, g/L | 0.003 | |||
| < 4 | Ref | |||
| ≥ 4 | 1.471 (1.137-1.904) | |||