Table 2. . Common medications that may inhibit or induce CYP2C19 or CYP2D6 enzyme activity.
Inhibitor(s) | Inducer(s) | |
---|---|---|
CYP2C19 | Strong: – Fluconazole – Fluoxetine – Fluvoxamine Moderate: –– Weak: – Omeprazole – Voriconazole |
Strong: – Rifampin – Ritonavir Moderate: – Efavirenz – Phenytoin Weak: –– |
CYP2D6 | Strong: – Bupropion – Fluoxetine – Paroxetine Moderate: – Cimetidine – Duloxetine – Fluvoxamine Weak: – Amiodarone – Celecoxib – Cimetidine – Desvenlafaxine – Escitalopram – Labetalol – Ritonavir – Sertraline |
None |
Source: FDA, drug development and drug interactions: table of substrates, inhibitors and inducers. Available at: www.fda.gov/Drugs/default.htm (accessed July 24, 2019).