Table 6.

ToxCast Bioactivity data and Model prediction scores (AUC values) for ER and AR activities for p,p’-DDD and Analogues^a

	p,p’-DDD	p,p’-DDT	p,p’-DDE	Methoxychlor
ER Assays
Active/Total Assays (%)	7/18 (39)	11/18 (61)	8/18 (44)	14/18 (78)
AC50 values (μM)	Range = 14.0 – 32.4 Median = 18.7	Range = 3.3 – 59.8 Median = 6.1	Range = 3.5–46.2 Median = 16.5	Range = 0.9 – 44.2 Median = 4.6
Agonist AUC values (95% CI)b	0.0715 (0.0342–0.0738)	0.190 (0.181–0.231)	0.0679 (0.0614–0.0963)	0.254 (0.247–0.260)
Antagonist AUC values (95% CI)	0	0	0	0
AR assays
Active/Total Assays (%)	4/11 (36)	3/11 (27)	4/11 (36)	3/11 (27)
AC50 values (μM)	Range = 31.0–62.8 Median = 44.8	Range = 17.8–72.0 Median = 47.0	Range = 7.0 – 58.7 Median = 29.6	Range = 29.3 – 40.8 Median = 34.2
Agonist AUC values (95% CI)	0	0	0	0
Antagonist AUC values (95% CI)	0.0973 (0.0649–0.124)	0.0642 (0.0318–0.108)	0.251 (0.234–0.291)	0.0429 (0.0364–0.0465)

^aData for ER and AR activities were sourced from Judson et al., (2015) and Kleinstreuer et al., (2016), respectively.

^b95% CI for the ER activity model were sourced from a subsequent publication to the Judson et al., (2015) study (Watt and Judson, 2018).

AUC = area under the curve score ranging from 0–1. An AUC value of 0 indicates that the chemcial is inactive.

CI = confidence interval.