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. 2019 Nov 13;26(5):623–637.e8. doi: 10.1016/j.chom.2019.09.016

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© 2019 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Relevant Residues on HIV-1 PVs for LN01 Binding

(A) HIV-2 chimera containing HIV-1 MPER region and parental HIV-2 were used to determined the binding of recombinant LN01. In the table are shown the IC50 (mg/mL) calculated based on the neutralization assay with TZM-bl cells (middle column), and the different mutations in the sequence carried by MPER of each chimeras (right column).

(B) The activities of LN01, 10E8, and 4E10 mAbs against several MPER mutants of the COT6.15 virus were assessed. Shown are the IC50 values expressed in μg/mL.