FIG 6.

Mutational frequency during H1N1p experimental passage in pooled mouse groups. Single nucleotide variants (SNVs) are represented along the genome segments for the plasmid and virus stocks (black stars), C57BL/6 mice of series 1 (blue circles), CMAH^−/− mice of series 1 (blue squares), C57BL/6 mice of series 2 (orange triangles), and CMAH^−/− mice of series 2 (orange diamonds). SNVs present at >20% are annotated for their resulting protein sequence changes.