FIG 7.

Mutational frequencies during H3N2ca experimental passage in pooled mouse groups. Single nucleotide variants (SNVs) are represented along the genome segments for the plasmid and virus stocks (black stars), C57BL/6 mice of series 1 (green circles), CMAH^−/− mice of series 1 (green squares), C57BL/6 mice of series 2 (black triangles), and CMAH^−/− mice of series 2 (black diamonds). SNVs present at >20% are annotated for their resulting protein sequence changes.