FIG 2.
Treatment with two antibiotics, ampicillin and vancomycin, was sufficient to reduce CVB3 shedding and lethality. Male C57BL/6 PVR+/+ IFNAR−/− mice were left untreated or treated with various antibiotics for 5 days by oral gavage followed by administration in drinking water available ad libitum for 9 days prior to oral inoculation with 5 × 107 PFU of CVB3. (A) Viral titers in feces specimens collected at 72 h postinoculation were determined by plaque assay. Data represent means ± SEM. *, P < 0.05; **, P < 0.001; ***, P < 0.0001 (Mann-Whitney test). Abx cocktail, five-antibiotic cocktail. (B) Survival of untreated or ampicillin-and-vancomycin-treated mice. *, P < 0.05 (log rank test). n = 12 to 17 mice per group from 3 independent experiments.