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. 2019 Nov 7;30(11):1405–1418. doi: 10.1089/hum.2019.019

FIG. 5.

FIG. 5.

pDNA miR-200c promotes bone regeneration in rat calvarial critical-size defect. (A) Surgical photograph of rat calvarial defects at 10 mm in diameter treated with pDNA miR-200c. (B) μCT top view image of critical-sized defect 6 weeks after receiving the implantation of collagen sponge loaded with different doses of pDNA miR-200c. (C, D) Quantitative measurement of BV/TV and BMD in the rat CB defects 6 weeks after receiving different treatments. *p < 0.05; n = 3. (E) Microphotographs of histological cross section of the critical size defects of rat calvaria 6 weeks after different treatments. H&E staining, bar = 1 mm; arrow: the edges of defects. Color images are available online.