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. 2019 Oct 16;20(6):4883–4892. doi: 10.3892/mmr.2019.10750

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Immune-mediated hepatitis is induced by ConA injection. (A) C57 BL/6 mice were injected with ConA (15 mg/kg) via the tail vein and sacrificed at 0, 6, 12, 24, and 48 h post-injection. The liver tissues were harvested and analyzed by H&E staining (n=6 in each group; ×100 and ×200 magnification). (B and C) The plasma ALT and AST levels of the mice were detected using an automatic biochemistry analysis apparatus (n=6). (D) The mRNA expression of TNF-α and IFN-γ in the mouse livers was analyzed by real-time PCR (n=6). **P<0.01, ***P<0.001 vs. the 0-h group. ConA, concanavalin A; ALT, alanine transaminase; AST, aspartate transaminase; TNF-α, tumor necrosis factor-α; IFN-γ, interferon-γ.