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. 2019 Oct 16;20(6):4883–4892. doi: 10.3892/mmr.2019.10750

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Tofacitinib effectively ameliorates inflammation in mice with ConA-induced acute hepatitis. (A) Male C57BL/6 mice that were administered with tofacitinib in advance by gavage were sacrificed 24 h after the ConA injection. Representative H&E staining of the liver tissues was performed to determine the therapeutic effects of tofacitinib (n=6; ×100 and ×200 magnification). (B) The serum levels of ALT and AST were detected using an automatic biochemistry analysis apparatus (n=6). ^##P<0.01 vs. the control group. *P<0.05 vs. the ConA-treated group. (C) Representative gross observation of the livers of the mice from the different groups that were administered with tofacitinib was performed (n=6). ConA, concanavalin A; ALT, alanine transaminase; AST, aspartate transaminase.