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. 2019 Oct 16;20(6):4883–4892. doi: 10.3892/mmr.2019.10750

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Tofacitinib suppresses the hepatic expression of pro-inflammatory cytokines in mice with ConA-induced hepatitis. (A) Several cytokines in the serum of mice from each group were detected using a CBA kit (n=3). ^#P<0.05, ^##P<0.01 vs. the control group. *P<0.05, **P<0.01 vs. the ConA-treated group. (B) Western blotting was used to analyze the expression of IFN-γ and TNF-α in the liver tissue samples from the mouse model with ConA-induced acute hepatitis (n=6). (C) Immunohistochemical staining was performed to detect the expression of IL-6 and IL-10 in the mouse livers (n=6; ×200 magnification). ConA, concanavalin A; ALT, alanine transaminase; AST, aspartate transaminase; TNF-α, tumor necrosis factor-α; IFN-γ, interferon-γ; IL-6, interleukin 6; IL-10, interleukin 10.