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. 2019 Oct 16;20(6):4883–4892. doi: 10.3892/mmr.2019.10750

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Tofacitinib restores the impaired Treg/Th17 cell ratio in mice with ConA-induced hepatitis. (A and C) Mononuclear cells were harvested from the livers 24 h after the ConA injection. The percentages of CD4⁺CD25⁺Foxp3⁺ Tregs and CD4⁺IL-17A⁺ Th17 cells were examined in the spleens and livers of the mice from the different experimental groups by flow cytometry (n=5). Representative images are presented. (B and D) Statistical graph of the Treg/Th17 cell ratio in the livers and spleens of mice from the different experimental groups. *P<0.05, **P<0.01, ***P<0.001. ConA, concanavalin A; Treg, regulatory T cells; Th17, Th17 cells.

Figure 5. — Tofacitinib restores the impaired Treg/Th17 cell ratio in mice with ConA-induced hepatitis. (A and C) Mononuclear cells were harvested from the livers 24 h after the ConA injection. The percentages of CD4⁺CD25⁺Foxp3⁺ Tregs and CD4⁺IL-17A⁺ Th17 cells were examined in the spleens and livers of the mice from the different experimental groups by flow cytometry (n=5). Representative images are presented. (B and D) Statistical graph of the Treg/Th17 cell ratio in the livers and spleens of mice from the different experimental groups. *P<0.05, **P<0.01, ***P<0.001. ConA, concanavalin A; Treg, regulatory T cells; Th17, Th17 cells.