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. 2019 Oct 23;20(6):4915–4924. doi: 10.3892/mmr.2019.10763

Figure 4.

Figure 4.

NTCP molecular alteration caused by the solute carrier family 10 member 1 variant c.595A>C(p.Ser199Arg). The figure illustrates a ball-and-stick model of the human NTCP protein. The solid lines in white, red and blue represent carbon, oxygen and nitrogen atoms, respectively, while the dashed lines in green represent hydrogen bonds. (A) In the wild-type model, the serine at position 199 in NTCP was not associated with the proline at position 286. (B) In the mutant NTCP model, the serine at position 199 was changed to an arginine. This change led to the formation of a new hydrogen bond between the arginine and proline (denoted by the yellow arrow). Meanwhile, the hydrogen bond lengths between the Gly at 190 and the Ile at 194, the Gly at 190 and Ile at 193, the Gly at 191 and Ile at 195, the Met at 192 and Leu at 196 as well as the Ile at 195 and Cys at 198, were changed from 3.17, 3.3, 2.85, 2.86 and 3.15 Å to 3.21, 3.27, 2.83, 2.79 and 3.3 Å, respectively. The changes in the hydrogen bonds resulted in structural distortion of the normal NTCP molecule. NTCP, sodium taurocholate cotransporting polypeptide.