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. 2019 Oct 25;20(6):5100–5110. doi: 10.3892/mmr.2019.10772

Figure 2.

Figure 2.

Autophagy flux is impaired in bone cancer pain mice. (A) Representative western blotting images of LC3BI/II and p62 protein expression in the spinal cord of mice in the Sham and Tumor groups on day 0, 4, 7, 10, 14, 21 and 28 post-operation. (B) Ratio of LC3B-II/LC3B-I and (C) quantification of p62 in the spinal cord in BCP. *P<0.05 vs. Sham group. (D) Representative blots of LC3BI/II and p62 protein expression in mice in the Sham and Tumor groups treated with or without Baf-A1 (10 nM). (E) Ratio of LC3B-II/LC3B-I and (F) quantification of p62. For all western blots, β-actin was used as a loading control. Data are expressed as the mean ± SD; n=3; *P<0.05 vs. Sham + vehicle mice. LC3B, microtubule-associated protein 1 light chain 3β.