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. 2019 Nov 14;20:860. doi: 10.1186/s12864-019-6230-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Lipid profiling of the blood showed ability to alter cholesterol composition in midlife. a Significant difference in total cholesterol plasma concentration at harvest in young runners and between midlife high runners to midlife sedentary mice (young *p = 0.0124, midlife *p = 0.0282). b No significant difference in High Density Lipoprotein (HDL) plasma concentration between runners and sedentary mice. c Significant difference in Low Density Lipoprotein (LDL) plasma concentration between midlife high runners and midlife sedentary mice (*p = 0.0489). d No change in non-fasted glucose plasma concentration across all cohorts. e Significant decrease in in plasma triglyceride between young run and young sedentary concentration (*p = 0.0151). f Significant reduction in Non-Esterified Fatty Acid (NEFA) plasma concentrations between young run and young sedentary cohorts (*p = 0.0374)