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. 2019 Nov 14;20:860. doi: 10.1186/s12864-019-6230-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — General upregulation of Collagens and Laminins due to young running with an attenuated response at midlife. a Number of significant collagen, laminin or other genes in young ‘Hepatic Fibrosis’ and ‘GP6 Signaling’ pathways in the cortex and hippocampus. b Fold changes of genes enriching for ‘GP6 Signaling’ in the cortex. c Fold changes of genes enriching for ‘GP6 Signaling’ in the hippocampus. d Heatmap of Col4s and laminins in the cortex and hippocampus that are significant in young run compared to young sedentary, while not significant in midlife comparisons. e Examples of significant cortical genes found in (d) showing attenuated responses in midlife cohort contrasts compared to young. f Examples of significant hippocampal genes found in (d) showing various responses in midlife cohort contrasts compared to young