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. 2019 Nov 14;20:860. doi: 10.1186/s12864-019-6230-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Running young is more effective than running at midlife. a Depiction of transcriptional changes occurring in a young mouse due to running, including upregulation of collagens and laminins from astrocytes, pericytes and endothelial cells, as well as induction of the VEGFA-KDR-DLL4 angiogenesis pathway. b Depiction of molecular changes occurring in midlife mice due to running, including downregulation of collagens and laminins, and a trend for induction of early angiogenesis genes from astrocytes (MMP14, VEGFA) but an attenuated downstream angiogenesis response (FLT-1, DLL4, NOTCH1) in endothelial cells