Fig. 6.

circLMTK2 promotes GC cell growth and metastasis by sponging miR-150-5p (a) The re-introduction of circLMTK2 reversed the inhibitory effect of miR-150-5p on MGC-803 cell proliferation. MiR-150-5p inhibitors promoted MGC-803 cell proliferation. (b) The re-introduction of circLMTK2 reversed the inhibitory effect of miR-150-5p on DNA synthesis. MiR-150-5p inhibitors promoted GC cell DNA synthesis. The micrographs represent at least three experiments. Scale bar = 200 μm. (c) The suppressed migration of MGC-803 cells induced by miR-150-5p was restored via circLMTK2 re-introduction. MiR-150-5p inhibitors promoted GC cell migration and invasion in vitro. (a-c) The data are the means ± SEM of three experiments. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (Student’s t-test)