Fig. 2.

IL-1α-treated cultures administered with either a single or continuous (Cont.) dose of 250 ng/mL IL-1Ra for 24 days. Mean ± 95% confidence interval of cumulative sGAG release as percentage of total sGAG content measured every 2 days in a cartilage monoculture and b cartilage + synovium co-culture. Nitrite release in media of c cartilage monoculture and d cartilage + synovium co-culture. Cumulative collagen loss measured as percentage of total collagen content of tissues in e cartilage monoculture and f cartilage + synovium co-culture. Double arrow indicates intervention window during which therapy can be administered prior to loss of collagen from extracellular matrix. * vs untreated control, # vs IL-1, $ vs single-dose IL-1Ra, (p < 0.05). Statistical markers are color coordinated with all curves. All the data enclosed within similar markers are statistically significant