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. 2019 Nov 13;21:238. doi: 10.1186/s13075-019-2003-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — IL-1α-treated cultures administered with either a single or continuous (Cont.) dose of IL-1Ra. Cell metabolism of individual tissues in a cartilage monoculture and b cartilage + synovium co-culture. Rate of sGAG biosynthesis in cartilage tissue at day 16 in c cartilage monoculture and d cartilage + synovium co-culture. Data is presented as mean ± 95% confidence interval. * vs control, # vs IL-1, $ vs single-dose IL-1Ra, ^ vs corresponding cartilage monoculture (p < 0.05). Statistical markers are color coordinated with all bars