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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Mol Neurobiol. 2019 Jun 26;56(12):8392–8407. doi: 10.1007/s12035-019-01673-y

Fig. 5.

Fig. 5

Expression and functional relevance of CYP in the epileptic regions of the brain. (a, b) Representative western blots of (a) CYP isoform expression and densitometric (b) quantification normalized by β-actin. The majority of CYPs (CYP1A1, *p < 0.001; CYP2C9, *p < 0.001; CYP3A4, *p = 0.006 and CYP2E1, *p < 0.001) were overexpressed in EPI regions compared to NON-EPI (n = 16 subjects) counterparts. In contrast, CYP2D6 expression remained unaltered (p = 0.1) in both regions. Results are expressed as mean ± SEM (by Wilcoxon signed rank test). (c) Increased CYP contribution in metabolic conversion of 7-ethoxyresorufin to resorufin was evident in the epileptic brain region (*p < 0.05, n = 6). (d) An apparent direct correlation between levels of P-gp and CYP3A4 expression (*p = 0.006, r = 0.52) was identified in the EPI and NON-EPI regions among the subject cohort. The linear correlation (Pearson’s co-efficient, r) for this comparison was determined by one-way ANOVA.