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. 2019 Nov 14;17:146. doi: 10.1186/s12964-019-0448-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Embryo-derived extracellular vesicles (EVs) alter the expression of specific transcripts in endometrial cells. a, b Size profiles of embryo and embryo culture media derived nanoparticles strongly resemble a typical size profile of a population of comparable EVs. Gene expressions of c ZNF81, d Beta-2-microglobulin and e Beta actin in endometrial cells treated with human IVF day 3/5 normal/degenerating embryo-derived EVs, pure culture media derived EVs and untreated control. Isolated EVs were incubated with endometrial cells for 24 h and whole RNA of cells was quantified using qPCR. Data is presented as mean ± SEM. (*) p < 0.05 vs untreated control