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. 2019 Nov 13;7:298. doi: 10.1186/s40425-019-0752-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Kaplan-Meier curves for overall, disease-free and distant metastasis-free survival of patients grouped by their EBV-DNA level and then stratified according to the ICS. Plots show (a) overall survival, (b) disease-free survival and (c) distant metastasis-free survival in the EBV-DNA level > 2000 copy/mL subgroup and (d) overall survival, (e) disease-free survival and (f) distant metastasis-free survival in the EBV-DNA level ≤ 2000 copy/mL subgroup. Abbreviations: ICS, immune checkpoint signature; HR, hazard ratio; and CI, confidence interval