Table 2.

Protocol for the evaluation of the nutritional status of people with achondroplasia from birth

	Measures and data to register	Indices and results to be monitored
Anthropometric assessment (in all follow-up visit except skin folds, from 3 years old)	Weight Height and height sitting	BMI, Height/Weight, Rohrer Verify according to the reference percentile tables
	Cranial perimeter	Verify according to the reference percentile tables
	Skinfolds thicknesses (triceps, biceps, abdominal, suprailiac, subscapular, middle thigh and leg)	In the absence of predictive equations, apply a summary of folds
	Body perimeters (arm, waist, hip, gluteus, middle thigh, leg)	Waist circumference Waist/hip index
DEXA (in all follow-up visit)	Body composition: total fat mass, fat mass distribution	Android/gynoid fat mass ratio
Indirect calorimetry (every 2 years)	Value of resting energy expenditure Value of the respiratory coefficient	Compare with normal range
Dietary records (in all follow-up visit)	72 h registration Frequencies of food consumption	Assessment of energy intake, % of macronutrients and energy distribution, % of energy in each meal compared to the total Valuation of food and beverages consumption
Blood test (every years) Blood pressure (in all follow-up visit)	Fasting glycemia, insulinemia and lipidemia Leptin, Ghrelin, anorexigenic gastrointestinal hormones: Cholecystokinin (CCK), Tyrosine-tyrosine peptide (PYY), Pancreatic polypeptide (PP), Insulinotropic glucose-dependent polypeptide (GIP), Glucagon-like petptide 1 (GLP-1), Oxintomodulin (OXM), Glucagon-like petptide 2 (GLP-2), orexigenic and anorexigenic neuropeptides (Corticotropin-releasing hormone (CRH), melanocortin, agouti protein, cocaine- and amphetamine-regulated transcript (CART) and Melanin-concentrating hormone (MCH)) Cortisol, noradrenalin, thyroid hormones	Compare with normal range