Table 5.

Myeloid cell effect of specific MDSC miRNAs

miRNA	Day 4	Day 14	Function
hsa-miR-21-5p	↑	↓	Expressed in myeloid cells. Elevated levels enhance proliferation and block myeloid differentiation (Zhang et al. 2014. JI)
hsa-miR-17-5p	↑	↓	Plays an important role in regulating the suppressive potential of MDSCs via STAT3 (Zhang et al. 2011. JI)
hsa-miR-181a-5p	↑	↓	Expressed in myeloid cells. Elevated levels are known to induce MDSC proliferation (McClure et al. 2014. ASM)
hsa-miR-106a-5p	↑	↓	Influences myeloid development. Overexpression represses M-CSFR and limits myeloid differentiation (El-Gazzar et al. 2013. Innate Immunity)

The myeloid cell effects of the specific MDSC miRNAs that were found to have different expression patterns in MDSCs from septic patients at says 4 and 14 after initial infection