. 2019 Nov 13;23:355. doi: 10.1186/s13054-019-2628-x

Table 7.

Transcriptomic differences in MDSCS isolated 14 days after severe sepsis/septic shock compared to healthy controls

Expression	Gene name
Upregulated	ABCA13, ACVR1B, ADAM9, ANKRD34B, ANXA3, *ARG1, ARID5B, C19orf59, CD177, CD63, CDADC1, CEACAM1, CLU, DACH1, ELMO2, FAM20A, FBXO9, FBXW2, FCAR, FKBP5, GADD45A, GCLM, GCNT1, GPR141, GPR84, GSR, GYG1, HK3, HMGB2, HP, HPR, KIF1B, LCN2, LILRA5, LTF, MACF1, MAP 2K6, MAPK14, METTL7B, MIR4441, MIR4677, MKI67, MMP8, MMP9, MS4A4A, MS4A4E, PAG1, PECR, PFKFB2, PFKFB3, PLAC8, RETN, RGL4, RN5S22, S100A8, SAMSN1, SEL1L3, SLC26A8, SLC36A1, SNORA79, SYNE1, TCN1, TDRD9, TMEM14E, UGCG, UPP1, VCAN-AS1, ZNF407*
Downregulated	CACNA2D3, *CCL4, CDKN1C, CHST7, ENOSF1, FAIM3, FCER1A, GZMA, HES1, HLA-DQB1, HLA-DRB1, IL7R, KLRF1, LOC388796, MIR3201, MIR4759, PRF1, PSTK, PYHIN1, RAPH1, RNU7-13P, RNU7-63P, RNU7-64P, RNU7-69P, RNU7-6P, RNU7-7P, RNU7-85P*

Expression

Gene name

Upregulated

ABCA13, ACVR1B, ADAM9, ANKRD34B, ANXA3, ARG1, ARID5B, C19orf59, CD177, CD63, CDADC1, CEACAM1, CLU, DACH1, ELMO2, FAM20A, FBXO9, FBXW2, FCAR, FKBP5, GADD45A, GCLM, GCNT1, GPR141, GPR84, GSR, GYG1, HK3, HMGB2, HP, HPR, KIF1B, LCN2, LILRA5, LTF, MACF1, MAP 2K6, MAPK14, METTL7B, MIR4441, MIR4677, MKI67, MMP8, MMP9, MS4A4A, MS4A4E, PAG1, PECR, PFKFB2, PFKFB3, PLAC8, RETN, RGL4, RN5S22, S100A8, SAMSN1, SEL1L3, SLC26A8, SLC36A1, SNORA79, SYNE1, TCN1, TDRD9, TMEM14E, UGCG, UPP1, VCAN-AS1, ZNF407

Downregulated

CACNA2D3, CCL4, CDKN1C, CHST7, ENOSF1, FAIM3, FCER1A, GZMA, HES1, HLA-DQB1, HLA-DRB1, IL7R, KLRF1, LOC388796, MIR3201, MIR4759, PRF1, PSTK, PYHIN1, RAPH1, RNU7-13P, RNU7-63P, RNU7-64P, RNU7-69P, RNU7-6P, RNU7-7P, RNU7-85P

Bolded texts represent genes known to be important to MDSC function