Table 8.

Predicted activation or deactivation of specific pathways based on MDSC mRNA expression from septic day 14 patients

Diseases or function	Predicted activation state Z-score
Inflammatory response*	2.187
Growth of malignant tumor*	2.607
Proliferation of cancer cells*	2.414
Proliferation of lymphatic system cells#	− 2.351

The top pathways and their corresponding Z-score within the functional category in severe sepsis/septic shock patients 14 days after insult

*The pathway is predicted to have significant activation

^#The pathway is predicted to be downregulated