Table 9.

Day 14 septic MDSC miRs and their predicted gene targets

microRNA	Matched gene target
Downregulated
hsa-miR-3175	METTL7B, GPR84, LCN2, LTF, FKBP5, TMEM14E, UGCG, PAG1, FAIM3, ACVR1B, HES1, ABCA13, CLU, ARID5B, MS4A4A, CEACAM1, ELMO2, SLC36A1, PFKFB3, KIF1B, PFKFB2, MKI67, MAPK14, FBXO9, FBXW2, CHST7, GSR, FAM20A, CD63
hsa-miR-4443	PFKFB3, METTL7B, GCLM, KIF1B, MS4A4A, IL7R, CLU, ACVR1B, MAPK14, TDRD9, MMP8, SYNE1, SLC36A1, FKBP5, PLAC8, ABCA13, MKI67, LTF, FAM20A
hsa-miR-3921	PSTK, TDRD9, KLRF1, CEACAM1, FAIM3, ANKRD34B, KIF1B, CHST7, SLC36A1, ELMO2, PFKFB2, RAPH1, MAP 2 K6, IL7R, FKBP5, MARCH1, GCLM, C15orf37, METTL7B, C15ORF37, GCNT1, MKI67, PAG1, ENOSF1, FBXO9, GSR, MARC1, HLA-DRB1, FAM20A
Upregulated
hsa-miR-5000-5p	PLAC8, TMEM14E, PSTK, ADAM9, CEACAM1, IL7R, ANKRD34B, ABCA13, HLA-DQB1, CD177, CHST7, GCLM, GPR141, FKBP5, MAP 2 K6, GCNT1, RAPH1, GSR, FAM20A

List of select significant MDSC miRs from septic patients at day 14 and their predicted targets of significant genes of the same cells as analyzed by TargetScan software