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. 2019 Nov 14;11:159. doi: 10.1186/s13148-019-0759-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — APOBEC3γ promotes the PD-L1 and Bcl-w demethylation, while the DNMT1/PCNA/UHRF1 disruption promotes the LLT1 demethylation. qMSRE (as previously described) compare the relative methylation level of Bcl-w, LLT1, and PD-L1 genes in cells transiently transfected with the pcDNA.3.1 (Ctrl), pcDNA.3.1-UP plasmid, and with pcDNA.3.1-APOBEC3γ plasmids. pcDNA.3.1-UP is a plasmid encoding for a chimeric protein having the ability to selectively disrupt the DNMT1/UHRF1 interaction [3, 4]