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. 2019 Nov 13;19:284. doi: 10.1186/s12883-019-1500-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — HRs of association between AD and vitamin D deficiency (serum 25(OH)D < 20 ng/ml). The size of each square is proportional to the study’s weight. The estimated pooled HR was 1.34 (95%CI, 1.13 to 1.60) with high statistical significance (P < 0.0001). There was high heterogeneity among the studies (I² = 53.1%)