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. 2019 Nov 13;19:246. doi: 10.1186/s12903-019-0906-2

Table 4.

Mean CLR OTUs for each of 267 bacterial species in the overall cohort and by age categories, and its linear correlation with age

Rank Order* OTU Label Culture Status Socransky Complex Overall
Cohort
(N = 1219)
Age Categories (years) Linear Correlation
CLR OTU
Mean (SE)
50–59
(N = 239)
CLR OTU
Mean (SE)
60–69
(N = 554)
CLR OTU
Mean (SE)
≥70
(N = 426)
CLR OTU
Mean (SE)
p-value Pearson r p-value
1 Veillonella dispar N 8.25 (0.06) 8.23 (0.13) 8.11 (0.09) 8.45 (0.10) 0.045 0.08 0.008
2 Streptococcus oralis N Y 8.06 (0.05) 8.40 (0.11) 8.06 (0.08) 7.87 (0.09) 0.002 −0.10 <.001
3 Veillonella parvula N P 7.60 (0.07) 7.48 (0.15) 7.45 (0.09) 7.86 (0.11) 0.014 0.10 0.001
4 Fusobacterium nucleatum_subsp._vincentii N O 6.43 (0.08) 6.21 (0.17) 6.48 (0.11) 6.50 (0.13) 0.356 0.02 0.587
5 Selenomonas sputigena N 5.63 (0.08) 5.34 (0.17) 5.44 (0.12) 6.03 (0.14) 0.001 0.10 <.001
6 Fusobacterium nucleatum_subsp._animalis N 5.39 (0.07) 5.29 (0.14) 5.29 (0.10) 5.57 (0.12) 0.136 0.10 0.106
7 Campylobacter gracilis N O 5.19 (0.05) 5.02 (0.11) 5.15 (0.07) 5.33 (0.09) 0.052 0.10 0.016
8 Fusobacterium nucleatum_subsp._polymorphum N O 5.19 (0.07) 5.36 (0.15) 5.28 (0.09) 4.97 (0.12) 0.052 −0.10 0.019
9 Prevotella oris N 5.08 (0.09) 5.25 (0.18) 5.05 (0.13) 5.03 (0.16) 0.646 −0.10 0.118
10 Streptococcus sanguinis N Y 4.91 (0.07) 5.57 (0.15) 5.04 (0.10) 4.38 (0.13) <.001* −0.18 <.001*
11 Corynebacterium matruchotii N 4.81 (0.07) 4.87 (0.17) 4.86 (0.10) 4.70 (0.12) 0.550 −0.04 0.171
12 Selenomonas noxia N 4.81 (0.08) 4.63 (0.18) 4.69 (0.11) 5.06 (0.13) 0.049 0.10 <.001
13 Prevotella nigrescens N O 4.31 (0.10) 4.48 (0.21) 4.28 (0.15) 4.26 (0.18) 0.714 −0.03 0.370
14 Parvimonas micra N 4.29 (0.08) 4.08 (0.17) 4.35 (0.11) 4.33 (0.12) 0.401 0.00 0.967
15 Rothia dentocariosa U 4.28 (0.09) 4.46 (0.19) 4.38 (0.13) 4.04 (0.15) 0.113 −0.10 0.008
16 Fusobacterium sp._oral_taxon_203 N 4.23 (0.10) 4.08 (0.22) 4.36 (0.15) 4.16 (0.17) 0.497 −0.01 0.713
17 Streptococcus gordonii N Y 4.19 (0.08) 3.93 (0.18) 4.15 (0.12) 4.40 (0.13) 0.090 0.04 0.039
18 Granulicatella adiacens N 4.15 (0.06) 4.23 (0.14) 4.11 (0.09) 4.15 (0.10) 0.749 0.00 0.991
19 Streptococcus intermedius N Y 3.94 (0.10) 4.33 (0.21) 3.86 (0.15) 3.81 (0.16) 0.119 −0.10 0.016
20 Actinomyces naeslundii N B 3.85 (0.06) 4.00 (0.14) 3.88 (0.09) 3.72 (0.11) 0.230 −0.10 0.008
21 TM7_[G-1] sp._oral_taxon_346 P 3.78 (0.09) 3.63 (0.19) 3.90 (0.12) 3.70 (0.16) 0.421 0.00 0.917
22 Haemophilus parainfluenzae N 3.74 (0.09) 4.21 (0.19) 3.73 (0.13) 3.48 (0.15) 0.014 −0.10 0.004
23 Fusobacterium naviforme N 3.58 (0.08) 3.61 (0.18) 3.62 (0.12) 3.52 (0.14) 0.852 −0.03 0.294
24 Dialister invisus N 3.51 (0.08) 3.12 (0.16) 3.50 (0.11) 3.75 (0.13) 0.013 0.10 0.003
25 Capnocytophaga gingivalis N G 3.36 (0.08) 3.39 (0.18) 3.45 (0.11) 3.23 (0.13) 0.423 −0.04 0.172
26 Streptococcus cristatus N 3.27 (0.07) 3.17 (0.16) 3.27 (0.11) 3.32 (0.13) 0.776 0.01 0.754
27 Gemella morbillorum N 3.14 (0.09) 3.37 (0.20) 3.35 (0.13) 2.73 (0.16) 0.004 −0.11 <.001*
28 Streptococcus salivarius U 3.02 (0.08) 3.05 (0.18) 2.79 (0.13) 3.29 (0.14) 0.028 0.10 0.090
29 TM7_[G-1] sp._oral_taxon_349 N 2.99 (0.10) 2.71 (0.22) 3.15 (0.14) 2.95 (0.18) 0.251 0.04 0.204
30 Bacteroidales_[G-2] sp._oral_taxon_274 N 2.96 (0.10) 2.47 (0.22) 3.15 (0.14) 3.00 (0.16) 0.030 0.03 0.328
31 Campylobacter showae P O 2.89 (0.08) 3.00 (0.17) 2.81 (0.11) 2.93 (0.14) 0.609 −0.01 0.685
32 Veillonella atypica N 2.88 (0.09) 2.47 (0.20) 2.56 (0.13) 3.53 (0.14) <.001* 0.16 <.001*
33 Eikenella corrodens N 2.87 (0.07) 3.00 (0.15) 3.07 (0.10) 2.53 (0.12) 0.001 −0.11 <.001*
34 Capnocytophaga leadbetteri N 2.86 (0.09) 2.87 (0.20) 2.93 (0.13) 2.78 (0.16) 0.758 −0.03 0.334
35 Fretibacterium sp._oral_taxon_360 N 2.81 (0.11) 2.29 (0.23) 2.89 (0.16) 3.00 (0.19) 0.048 0.04 0.148
36 Prevotella sp._oral_taxon_317 N 2.73 (0.10) 2.79 (0.22) 2.68 (0.16) 2.76 (0.18) 0.907 −0.00 0.965
37 Capnocytophaga granulosa U 2.72 (0.09) 2.39 (0.21) 2.84 (0.13) 2.75 (0.16) 0.189 0.04 0.152
38 Alloprevotella tannerae N 2.71 (0.12) 2.69 (0.24) 2.78 (0.17) 2.64 (0.20) 0.865 0.01 0.788
39 Kingella oralis P 2.66 (0.08) 2.66 (0.19) 2.65 (0.11) 2.68 (0.14) 0.983 −0.01 0.847
40 TM7_[G-1] sp._oral_taxon_952 U 2.58 (0.10) 2.80 (0.22) 2.83 (0.14) 2.12 (0.16) 0.002 −0.10 <.001
41 Selenomonas artemidis N 2.51 (0.11) 2.77 (0.24) 2.39 (0.16) 2.52 (0.19) 0.419 −0.00 0.957
42 Campylobacter concisus N G 2.41 (0.06) 2.22 (0.14) 2.37 (0.10) 2.56 (0.11) 0.152 0.10 0.036
43 Actinomyces oris N B 2.36 (0.08) 2.63 (0.17) 2.37 (0.11) 2.18 (0.13) 0.104 −0.10 0.021
44 Treponema socranskii N 2.22 (0.07) 1.84 (0.17) 2.16 (0.11) 2.52 (0.13) 0.004 0.10 <.001
45 Cardiobacterium hominis N 2.21 (0.08) 2.50 (0.19) 2.45 (0.12) 1.75 (0.14) <.001* −0.11 <.001
46 Leptotrichia wadei N 2.15 (0.10) 2.21 (0.23) 1.94 (0.16) 2.38 (0.18) 0.159 0.03 0.305
47 Anaeroglobus geminatus P 2.12 (0.10) 1.32 (0.22) 1.94 (0.15) 2.79 (0.18) <.001* 0.17 <.001*
48 Gemella haemolysans N 2.11 (0.09) 2.42 (0.20) 2.10 (0.13) 1.96 (0.14) 0.161 −0.10 0.018
49 Capnocytophaga sputigena N G 2.11 (0.09) 2.31 (0.21) 2.23 (0.13) 1.84 (0.17) 0.113 −0.10 0.094
50 Rothia aeria N 2.11 (0.09) 2.49 (0.20) 2.42 (0.14) 1.48 (0.15) <.001* −0.15 <.001*
51 Bergeyella sp._oral_taxon_322 N 2.08 (0.07) 2.38 (0.16) 2.11 (0.10) 1.87 (0.11) 0.028 −0.10 0.008
52 Leptotrichia hongkongensis N 2.02 (0.09) 2.02 (0.21) 1.94 (0.14) 2.13 (0.16) 0.660 0.03 0.337
53 Rothia mucilaginosa U 1.95 (0.08) 1.79 (0.17) 1.90 (0.11) 2.09 (0.13) 0.321 0.03 0.237
54 Prevotella melaninogenica N 1.90 (0.08) 1.75 (0.17) 1.78 (0.12) 2.14 (0.14) 0.095 0.10 0.049
55 Actinomyces sp._oral_taxon_169 N 1.89 (0.09) 2.28 (0.20) 1.96 (0.13) 1.59 (0.15) 0.016 −0.10 <.001
56 Tannerella forsythia N R 1.87 (0.10) 1.50 (0.21) 1.80 (0.14) 2.18 (0.17) 0.042 0.10 0.029
57 Selenomonas sp._oral_taxon_136 N 1.86 (0.08) 1.21 (0.18) 1.76 (0.12) 2.36 (0.15) <.001* 0.16 <.001*
58 Catonella morbi N 1.86 (0.08) 2.08 (0.17) 1.89 (0.11) 1.69 (0.13) 0.184 −0.10 0.020
59 Prevotella denticola N 1.74 (0.10) 1.46 (0.23) 1.60 (0.15) 2.10 (0.18) 0.040 0.10 0.006
60 Neisseria sicca N 1.72 (0.11) 1.58 (0.25) 1.88 (0.16) 1.60 (0.18) 0.416 −0.01 0.678
61 Peptostreptococcaceae_[XI][G-9] [Eubacterium]_brac U 1.70 (0.08) 2.08 (0.16) 1.72 (0.12) 1.47 (0.14) 0.030 −0.10 0.003
62 Neisseria elongata N 1.63 (0.10) 1.95 (0.25) 1.81 (0.15) 1.22 (0.17) 0.012 −0.10 0.008
63 Cardiobacterium valvarum U 1.49 (0.09) 1.60 (0.21) 1.63 (0.13) 1.26 (0.14) 0.137 −0.10 0.044
64 Porphyromonas sp._oral_taxon_279 P 1.49 (0.09) 1.46 (0.20) 1.62 (0.13) 1.34 (0.16) 0.394 −0.02 0.494
65 Selenomonas infelix U 1.48 (0.08) 1.56 (0.17) 1.44 (0.12) 1.50 (0.15) 0.871 −0.01 0.709
66 Leptotrichia sp._oral_taxon_212 U 1.44 (0.09) 1.63 (0.21) 1.64 (0.13) 1.08 (0.16) 0.013 −0.10 0.011
67 Actinomyces sp._oral_taxon_180 N 1.44 (0.07) 1.54 (0.15) 1.45 (0.10) 1.38 (0.11) 0.704 −0.03 0.235
68 Prevotella sp._oral_taxon_300 N 1.43 (0.09) 1.31 (0.19) 1.24 (0.13) 1.75 (0.15) 0.025 0.10 0.007
69 Prevotella maculosa N 1.42 (0.08) 1.07 (0.17) 1.32 (0.11) 1.75 (0.13) 0.003 0.10 0.001
70 Streptococcus mutans N 1.39 (0.11) 0.98 (0.24) 1.19 (0.16) 1.87 (0.20) 0.005 0.10 <.001
71 Actinomyces massiliensis N B 1.38 (0.07) 1.68 (0.17) 1.50 (0.10) 1.05 (0.11) 0.002 −0.12 <.001*
72 Fretibacterium fastidiosum N 1.30 (0.10) 1.12 (0.22) 1.25 (0.15) 1.47 (0.17) 0.393 0.04 0.173
73 Veillonellaceae_[G-1] sp._oral_taxon_150 N 1.23 (0.09) 0.74 (0.20) 1.00 (0.13) 1.81 (0.16) <.001* 0.14 <.001*
74 Neisseria flavescens N 1.23 (0.10) 0.98 (0.21) 1.28 (0.14) 1.30 (0.17) 0.425 0.02 0.533
75 Prevotella oulorum P 1.22 (0.09) 1.23 (0.20) 1.00 (0.13) 1.50 (0.15) 0.041 0.10 0.059
76 Streptococcus anginosus N Y 1.17 (0.11) 1.03 (0.23) 0.92 (0.16) 1.56 (0.19) 0.024 0.10 0.013
77 Lachnoanaerobaculum saburreum N 1.07 (0.08) 0.85 (0.18) 1.12 (0.12) 1.13 (0.14) 0.384 0.04 0.208
78 Veillonellaceae_[G-1] sp._oral_taxon_155 N 1.00 (0.09) 0.66 (0.20) 0.84 (0.13) 1.39 (0.15) 0.004 0.10 <.001
79 Selenomonas sp._oral_taxon_892 L 0.98 (0.08) 1.18 (0.19) 1.05 (0.12) 0.76 (0.15) 0.148 −0.10 0.030
80 Actinomyces johnsonii N B 0.97 (0.07) 1.18 (0.16) 0.92 (0.11) 0.92 (0.12) 0.365 −0.04 0.229
81 Selenomonas sp._oral_taxon_137 U 0.95 (0.11) 0.95 (0.25) 1.21 (0.17) 0.61 (0.20) 0.064 −0.04 0.145
82 Corynebacterium durum U 0.93 (0.08) 1.53 (0.19) 1.07 (0.12) 0.42 (0.13) <.001* −0.15 <.001*
83 Lautropia mirabilis U 0.88 (0.09) 1.28 (0.21) 0.99 (0.13) 0.53 (0.15) 0.006 −0.10 <.001
84 Veillonella rogosae N 0.87 (0.09) 1.06 (0.20) 1.08 (0.13) 0.49 (0.16) 0.010 −0.10 <.001
85 Leptotrichia sp._oral_taxon_417 N 0.86 (0.09) 0.41 (0.20) 0.95 (0.13) 1.01 (0.16) 0.048 0.10 0.006
86 Selenomonas flueggei N 0.81 (0.08) 0.58 (0.18) 0.81 (0.12) 0.93 (0.14) 0.317 0.04 0.122
87 Selenomonas sp._oral_taxon_134 P 0.77 (0.10) 0.55 (0.21) 0.75 (0.14) 0.94 (0.18) 0.367 0.03 0.251
88 Streptococcus parasanguinis_II U 0.74 (0.09) 0.58 (0.19) 0.49 (0.13) 1.15 (0.15) 0.003 0.11 <.001*
89 Megasphaera micronuciformis N 0.70 (0.08) 0.47 (0.19) 0.46 (0.13) 1.14 (0.14) <.001 0.12 <.001*
90 Capnocytophaga sp._oral_taxon_336 N 0.69 (0.09) 0.68 (0.19) 0.69 (0.13) 0.71 (0.16) 0.991 0.02 0.480
91 Oribacterium sp._oral_taxon_078 U 0.66 (0.08) −0.03 (0.17) 0.51 (0.11) 1.26 (0.14) <.001* 0.18 <.001*
92 Actinomyces sp._oral_taxon_171 P 0.66 (0.08) 0.82 (0.18) 0.66 (0.12) 0.57 (0.13) 0.527 −0.10 0.090
93 Lachnospiraceae_[G-3] sp._oral_taxon_100 U 0.59 (0.08) 0.60 (0.18) 0.73 (0.12) 0.41 (0.14) 0.200 −0.03 0.239
94 Parvimonas sp._oral_taxon_393 U 0.58 (0.11) 1.11 (0.24) 0.63 (0.16) 0.22 (0.17) 0.010 −0.12 <.001*
95 Actinomyces gerencseriae N B 0.56 (0.07) 0.49 (0.17) 0.37 (0.11) 0.86 (0.13) 0.012 0.10 0.008
96 Dialister pneumosintes P 0.55 (0.09) 0.64 (0.20) 0.42 (0.14) 0.65 (0.16) 0.477 0.03 0.357
97 Kingella denitrificans N 0.54 (0.09) 0.21 (0.20) 0.45 (0.13) 0.84 (0.15) 0.025 0.10 0.024
98 Porphyromonas endodontalis N 0.52 (0.12) 1.09 (0.27) 0.56 (0.17) 0.13 (0.20) 0.015 −0.10 <.001
99 TM7_[G-5] sp._oral_taxon_356 P 0.49 (0.11) 0.30 (0.23) 0.61 (0.16) 0.43 (0.19) 0.517 0.02 0.580
100 Selenomonas sp._oral_taxon_919 U 0.47 (0.08) 0.72 (0.18) 0.45 (0.12) 0.35 (0.15) 0.287 −0.10 0.096
101 Leptotrichia buccalis N 0.45 (0.10) 0.23 (0.23) 0.77 (0.14) 0.16 (0.16) 0.011 −0.03 0.375
102 Prevotella sp._oral_taxon_472 N 0.45 (0.10) 0.65 (0.23) 0.80 (0.15) −0.13 (0.17) <.001* −0.10 <.001
103 Capnocytophaga sp._oral_taxon_326 P 0.41 (0.10) 0.38 (0.23) 0.62 (0.15) 0.15 (0.17) 0.121 −0.10 0.080
104 Streptococcus constellatus N O 0.35 (0.10) 0.25 (0.21) 0.18 (0.15) 0.63 (0.17) 0.114 0.04 0.139
105 Prevotella salivae N 0.34 (0.08) −0.22 (0.18) 0.32 (0.12) 0.69 (0.14) <.001 0.15 <.001*
106 Leptotrichia sp._oral_taxon_392 U 0.33 (0.09) 0.49 (0.20) 0.58 (0.13) − 0.08 (0.15) 0.003 −0.10 0.001
107 Actinobaculum sp._oral_taxon_183 N 0.32 (0.08) 0.29 (0.17) 0.28 (0.12) 0.40 (0.14) 0.765 0.01 0.742
108 Neisseria oralis U 0.31 (0.11) 0.47 (0.25) 0.35 (0.15) 0.19 (0.18) 0.618 −0.04 0.133
109 Atopobium rimae N 0.21 (0.09) −0.08 (0.19) 0.17 (0.13) 0.43 (0.16) 0.124 0.10 0.108
110 Leptotrichia hofstadii N 0.20 (0.10) 0.10 (0.22) 0.27 (0.15) 0.17 (0.17) 0.804 0.01 0.743
111 Streptococcus sp._oral_taxon_074 N 0.15 (0.07) 0.15 (0.16) 0.25 (0.11) 0.02 (0.12) 0.340 −0.04 0.154
112 Fretibacterium sp._oral_taxon_359 L 0.15 (0.11) 0.14 (0.25) 0.04 (0.16) 0.30 (0.18) 0.537 0.02 0.552
113 Leptotrichia shahii U 0.11 (0.10) 0.30 (0.22) −0.09 (0.15) 0.26 (0.19) 0.209 0.03 0.298
114 Tannerella sp._oral_taxon_286 U 0.11 (0.07) − 0.15 (0.16) 0.26 (0.10) 0.06 (0.13) 0.101 0.03 0.370
115 Porphyromonas sp._oral_taxon_284 N 0.08 (0.10) 0.14 (0.21) 0.22 (0.14) − 0.14 (0.16) 0.223 −0.10 0.080
116 Peptostreptococcaceae_[XI][G-7] [Eubacterium]_yuri P 0.05 (0.10) 0.50 (0.21) 0.19 (0.14) −0.40 (0.16) 0.001 −0.14 <.001*
117 Selenomonas sp._oral_taxon_146 L 0.04 (0.08) 0.04 (0.18) − 0.03 (0.12) 0.14 (0.14) 0.659 0.014 0.633
118 Fusobacterium periodonticum N O −0.02 (0.07) −0.12 (0.16) 0.13 (0.11) −0.17 (0.13) 0.174 −0.02 0.488
119 Actinomyces meyeri L B −0.04 (0.08) 0.29 (0.18) 0.05 (0.12) − 0.35 (0.13) 0.010 −0.11 <.001*
120 Leptotrichia sp._oral_taxon_215 N − 0.05 (0.08) 0.16 (0.18) 0.01 (0.12) − 0.24 (0.14) 0.157 −0.04 0.170
121 Prevotella oralis N − 0.06 (0.10) −0.34 (0.20) − 0.13 (0.14) 0.20 (0.17) 0.105 0.10 0.030
122 Prevotella pleuritidis N − 0.10 (0.12) −0.07 (0.27) 0.09 (0.18) −0.38 (0.20) 0.211 −0.04 0.190
123 Abiotrophia defectiva N −0.15 (0.09) −0.05 (0.19) − 0.01 (0.13) − 0.38 (0.14) 0.138 − 0.10 0.028
124 Gemella sanguinis N −0.19 (0.07) −0.16 (0.15) − 0.35 (0.10) − 0.00 (0.12) 0.077 0.04 0.204
125 Fusobacterium nucleatum_subsp._nucleatum N O −0.25 (0.08) −0.44 (0.17) − 0.30 (0.11) − 0.08 (0.14) 0.209 0.03 0.259
126 Atopobium parvulum N − 0.25 (0.08) −0.28 (0.17) − 0.47 (0.11) 0.06 (0.14) 0.009 0.10 0.005
127 Aggregatibacter sp._oral_taxon_458 N − 0.25 (0.09) − 0.11 (0.19) − 0.17 (0.13) − 0.44 (0.15) 0.309 −0.10 0.047
128 Streptococcus parasanguinis_I N − 0.26 (0.08) −0.29 (0.17) − 0.48 (0.11) 0.05 (0.13) 0.008 0.10 0.008
129 Aggregatibacter aphrophilus N − 0.27 (0.11) −0.18 (0.25) − 0.01 (0.17) − 0.66 (0.18) 0.027 − 0.10 0.015
130 Treponema denticola N R −0.28 (0.10) −0.16 (0.22) − 0.25 (0.15) − 0.39 (0.18) 0.692 − 0.04 0.211
131 Prevotella saccharolytica U − 0.37 (0.07) − 0.38 (0.16) − 0.26 (0.11) − 0.51 (0.13) 0.336 − 0.01 0.663
132 TM7_[G-1] sp._oral_taxon_488 P − 0.39 (0.10) − 0.39 (0.22) − 0.11 (0.15) − 0.76 (0.16) 0.015 −0.04 0.132
133 Johnsonella ignava U − 0.41 (0.09) −0.50 (0.21) − 0.34 (0.14) − 0.45 (0.16) 0.783 − 0.01 0.783
134 Actinomyces israelii N B −0.47 (0.06) −0.65 (0.13) − 0.52 (0.09) − 0.30 (0.11) 0.091 0.10 0.012
135 Lachnoanaerobaculum umeaense P − 0.47 (0.07) −0.35 (0.17) − 0.39 (0.11) − 0.65 (0.12) 0.198 −0.03 0.316
136 Streptococcus sp._oral_taxon_056 U − 0.49 (0.08) −0.38 (0.19) − 0.37 (0.12) − 0.73 (0.14) 0.127 −0.04 0.050
137 Olsenella sp._oral_taxon_807 N − 0.49 (0.07) −0.93 (0.15) − 0.50 (0.10) − 0.25 (0.12) 0.002 0.11 <.001*
138 Solobacterium moorei U − 0.51 (0.06) −0.49 (0.15) − 0.60 (0.09) − 0.42 (0.11) 0.437 0.04 0.221
139 Treponema maltophilum P − 0.53 (0.08) −0.78 (0.16) − 0.59 (0.11) − 0.32 (0.13) 0.070 0.10 0.040
140 TM7_[G-1] sp._oral_taxon_348 N − 0.53 (0.08) − 0.66 (0.17) − 0.29 (0.13) − 0.77 (0.14) 0.026 − 0.03 0.373
141 Porphyromonas gingivalis N R −0.56 (0.12) −0.70 (0.26) − 0.60 (0.17) − 0.43 (0.22) 0.688 0.03 0.348
142 Centipeda periodontii N − 0.60 (0.08) − 0.94 (0.15) − 0.55 (0.11) − 0.47 (0.13) 0.074 0.06 0.031
143 Selenomonas sp._oral_taxon_126 N − 0.60 (0.08) −0.77 (0.18) − 0.56 (0.12) − 0.56 (0.14) 0.588 0.03 0.386
144 Desulfobulbus sp._oral_taxon_041 U −0.66 (0.10) −1.02 (0.20) − 0.70 (0.14) − 0.40 (0.17) 0.064 0.10 0.027
145 Alloprevotella rava U −0.68 (0.08) −0.78 (0.18) − 0.64 (0.12) − 0.69 (0.14) 0.809 0.02 0.464
146 Actinobaculum sp._oral_taxon_848 P − 0.70 (0.08) −0.83 (0.17) − 0.82 (0.11) −0.46 (0.13) 0.080 0.10 0.016
147 Stomatobaculum longum N − 0.70 (0.07) − 0.95 (0.16) − 0.76 (0.11) −0.48 (0.13) 0.054 0.11 <.001
148 Prevotella histicola N − 0.75 (0.09) − 0.96 (0.18) −1.04 (0.13) − 0.26 (0.16) <.001 0.11 <.001*
149 Aggregatibacter segnis U − 0.79 (0.10) − 0.42 (0.22) − 0.69 (0.14) −1.13 (0.15) 0.020 − 0.11 <.001*
150 Leptotrichia sp._oral_taxon_225 N − 0.80 (0.10) − 0.43 (0.22) − 0.60 (0.15) − 1.25 (0.15) 0.002 − 0.11 <.001*
151 Ruminococcaceae_[G-1] sp._oral_taxon_075 N − 0.80 (0.08) − 0.79 (0.17) − 0.69 (0.12) −0.94 (0.13) 0.350 −0.03 0.341
152 Peptostreptococcus stomatis U − 0.80 (0.09) −0.50 (0.19) − 0.77 (0.13) − 1.02 (0.14) 0.085 − 0.10 0.032
153 Porphyromonas catoniae P − 0.92 (0.09) − 0.50 (0.20) − 0.79 (0.13) −1.31 (0.14) 0.002 − 0.10 <.001
154 Actinomyces sp._oral_taxon_178 P −0.93 (0.06) − 1.15 (0.14) − 0.94 (0.09) − 0.78 (0.10) 0.099 0.05 0.080
155 Prevotella pallens N − 0.93 (0.08) −1.00 (0.17) − 1.05 (0.11) −0.73 (0.14) 0.191 0.10 0.054
156 Filifactor alocis U − 0.94 (0.10) −0.66 (0.23) − 0.98 (0.15) − 1.05 (0.18) 0.382 − 0.10 0.077
157 Selenomonas sp._oral_taxon_936 P −0.96 (0.08) − 0.91 (0.17) −1.05 (0.12) − 0.87 (0.14) 0.578 0.03 0.323
158 TM7_[G-1] sp._oral_taxon_347 N − 0.97 (0.09) −0.64 (0.20) − 0.95 (0.14) −1.17 (0.14) 0.107 − 0.10 0.071
159 Haemophilus sp._oral_taxon_036 N −1.01 (0.09) − 0.65 (0.19) − 1.00 (0.13) − 1.21 (0.15) 0.075 − 0.10 0.002
160 Prevotella sp._oral_taxon_292 P − 1.06 (0.08) − 1.34 (0.17) − 1.15 (0.12) −0.79 (0.15) 0.040 0.10 0.001
161 Leptotrichia sp._oral_taxon_498 N − 1.07 (0.09) −1.28 (0.20) − 1.20 (0.13) −0.77 (0.16) 0.059 0.10 0.013
162 Capnocytophaga sp._oral_taxon_338 U − 1.08 (0.09) −1.17 (0.20) − 1.12 (0.13) −0.98 (0.15) 0.671 0.01 0.808
163 Alloprevotella sp._oral_taxon_308 N − 1.14 (0.07) −0.90 (0.14) −1.28 (0.10) − 1.10 (0.12) 0.111 −0.01 0.799
164 Treponema sp._oral_taxon_231 P − 1.15 (0.09) −1.04 (0.18) − 1.03 (0.13) − 1.36 (0.15) 0.206 − 0.10 0.074
165 TM7_[G-1] sp._oral_taxon_352 N − 1.15 (0.07) − 1.31 (0.15) − 1.11 (0.10) − 1.11 (0.12) 0.545 0.04 0.173
166 Prevotella buccae U − 1.23 (0.07) −1.71 (0.14) − 1.36 (0.11) − 0.78 (0.12) <.001* 0.14 <.001*
167 Prevotella loescheii N −1.24 (0.09) −0.96 (0.21) −0.97 (0.14) − 1.74 (0.15) <.001 − 0.10 0.001
168 Capnocytophaga sp._oral_taxon_864 U − 1.27 (0.08) −0.98 (0.20) −1.15 (0.13) − 1.57 (0.13) 0.020 − 0.10 0.005
169 Actinomyces sp._oral_taxon_170 U −1.29 (0.08) − 0.99 (0.19) − 1.16 (0.13) − 1.62 (0.13) 0.011 − 0.10 <.001
170 Lachnoanaerobaculum orale U − 1.31 (0.07) − 1.09 (0.16) − 1.46 (0.09) −1.23 (0.12) 0.085 0.02 0.513
171 Ottowia sp._oral_taxon_894 N − 1.31 (0.08) −1.44 (0.18) − 1.24 (0.12) − 1.33 (0.14) 0.662 −0.00 0.938
172 Streptococcus lactarius N − 1.32 (0.07) − 1.06 (0.15) − 1.46 (0.10) − 1.30 (0.12) 0.097 −0.02 0.414
173 Peptostreptococcaceae_[XI][G-1] [Eubacterium]_infi P − 1.33 (0.07) − 1.59 (0.15) − 1.41 (0.09) − 1.08 (0.12) 0.014 0.10 0.002
174 Leptotrichia sp._oral_taxon_219 N − 1.34 (0.07) −1.39 (0.17) − 1.27 (0.11) −1.39 (0.12) 0.736 −0.01 0.717
175 Prevotella intermedia P O −1.36 (0.11) −1.31 (0.25) − 1.35 (0.17) − 1.41 (0.18) 0.943 −0.04 0.181
176 Veillonella denticariosi U − 1.37 (0.09) − 1.51 (0.19) − 1.39 (0.13) − 1.27 (0.15) 0.621 0.04 0.156
177 Fretibacterium sp._oral_taxon_362 N − 1.43 (0.08) −1.48 (0.19) − 1.43 (0.12) − 1.42 (0.14) 0.965 0.00 0.888
178 Bacteroidetes_[G-5] sp._oral_taxon_511 U − 1.47 (0.09) − 1.44 (0.19) − 1.43 (0.14) − 1.54 (0.15) 0.846 −0.03 0.378
179 Prevotella sp._oral_taxon_313 P − 1.49 (0.08) −1.14 (0.18) − 1.75 (0.11) − 1.35 (0.14) 0.007 0.02 0.431
180 TM7_[G-3] sp._oral_taxon_351 P − 1.50 (0.06) −1.84 (0.13) − 1.39 (0.10) − 1.45 (0.11) 0.029 0.10 0.018
181 Streptococcus australis N − 1.51 (0.07) −1.62 (0.15) − 1.57 (0.11) − 1.38 (0.13) 0.373 0.03 0.295
182 Granulicatella elegans N − 1.59 (0.07) −1.18 (0.17) − 1.72 (0.11) −1.65 (0.12) 0.023 −0.10 0.067
183 TM7_[G-1] sp._oral_taxon_869 P − 1.60 (0.09) −1.64 (0.20) − 1.55 (0.14) − 1.64 (0.15) 0.890 0.01 0.663
184 Capnocytophaga sp._oral_taxon_902 N −1.65 (0.08) − 1.56 (0.19) − 1.68 (0.12) −1.67 (0.14) 0.860 −0.04 0.220
185 Prevotella dentalis P −1.66 (0.08) −1.65 (0.19) − 1.82 (0.12) −1.47 (0.14) 0.180 0.03 0.326
186 Campylobacter curvus N − 1.67 (0.07) −1.57 (0.17) − 1.79 (0.10) − 1.58 (0.13) 0.365 0.03 0.335
187 Pseudoramibacter alactolyticus P − 1.68 (0.08) − 2.18 (0.17) −1.73 (0.12) − 1.35 (0.15) 0.001 0.12 <.001*
188 TM7_[G-6] sp._oral_taxon_870 N − 1.71 (0.08) −1.47 (0.18) − 1.69 (0.12) − 1.85 (0.13) 0.220 −0.10 0.085
189 Veillonellaceae_[G-1] sp._oral_taxon_129 N − 1.71 (0.08) − 1.96 (0.16) − 1.80 (0.11) − 1.46 (0.14) 0.042 0.10 0.010
190 Tannerella sp._oral_taxon_808 U − 1.75 (0.07) −2.03 (0.14) −1.70 (0.10) − 1.65 (0.12) 0.104 0.10 0.011
191 Peptostreptococcaceae_[XI][G-6] [Eubacterium]_noda L − 1.75 (0.08) − 1.67 (0.18) − 1.90 (0.11) −1.61 (0.14) 0.238 0.02 0.425
192 Mitsuokella sp._oral_taxon_131 N − 1.79 (0.09) −2.18 (0.17) − 1.96 (0.13) − 1.36 (0.16) <.001 0.14 <.001*
193 Mycoplasma salivarium P − 1.80 (0.07) −1.77 (0.15) − 1.87 (0.11) − 1.71 (0.12) 0.579 0.03 0.302
194 Haemophilus haemolyticus P − 1.81 (0.08) −1.30 (0.19) − 1.92 (0.12) − 1.94 (0.12) 0.006 −0.10 0.043
195 Bergeyella sp._oral_taxon_907 P −1.81 (0.07) −1.86 (0.15) − 1.72 (0.10) − 1.92 (0.12) 0.405 − 0.01 0.765
196 TM7_[G-2] sp._oral_taxon_350 N − 1.82 (0.09) − 1.86 (0.18) − 1.82 (0.13) − 1.80 (0.15) 0.968 0.02 0.412
197 Prevotella veroralis U − 1.82 (0.08) −1.73 (0.18) − 1.78 (0.13) − 1.93 (0.13) 0.582 −0.02 0.413
198 Aggregatibacter paraphrophilus N − 1.82 (0.09) −1.48 (0.21) − 1.69 (0.14) −2.19 (0.13) 0.007 −0.10 <.001
199 Leptotrichia sp._oral_taxon_223 P − 1.82 (0.08) −1.71 (0.17) − 1.98 (0.11) − 1.69 (0.14) 0.206 0.02 0.499
200 Bifidobacterium dentium N − 1.85 (0.08) −2.10 (0.18) −2.12 (0.12) −1.37 (0.15) <.001* 0.15 <.001*
201 Alloprevotella sp._oral_taxon_473 U − 1.87 (0.08) −1.63 (0.17) − 1.88 (0.12) − 1.98 (0.13) 0.300 −0.10 0.030
202 Veillonellaceae_[G-1] sp._oral_taxon_145 U − 1.88 (0.08) −1.98 (0.16) − 1.83 (0.12) − 1.88 (0.14) 0.768 0.02 0.551
203 Neisseria bacilliformis N −1.89 (0.09) −1.82 (0.20) − 1.90 (0.13) − 1.93 (0.14) 0.906 −0.04 0.194
204 Capnocytophaga sp._oral_taxon_412 N − 1.89 (0.08) −1.74 (0.18) − 1.81 (0.12) −2.09 (0.13) 0.173 − 0.04 0.162
205 Neisseria subflava N − 1.89 (0.09) − 1.84 (0.18) −2.04 (0.13) − 1.73 (0.16) 0.267 0.10 0.118
206 Veillonella sp._oral_taxon_780 N − 1.94 (0.08) − 1.46 (0.20) − 1.93 (0.12) − 2.20 (0.12) 0.004 −0.10 <.001
207 Lachnospiraceae_[G-8] sp._oral_taxon_500 N − 1.94 (0.07) −1.91 (0.16) −2.03 (0.10) − 1.83 (0.12) 0.443 0.01 0.695
208 Capnocytophaga sp._oral_taxon_323 P −1.94 (0.08) −1.99 (0.17) − 1.93 (0.12) − 1.94 (0.14) 0.966 − 0.01 0.731
209 Scardovia wiggsiae P −1.94 (0.09) − 2.07 (0.19) − 2.11 (0.12) − 1.66 (0.16) 0.061 0.10 0.009
210 Sphingomonas echinoides N − 1.95 (0.06) −1.75 (0.14) − 1.89 (0.10) − 2.15 (0.11) 0.056 −0.10 <.001
211 SR1_[G-1] sp._oral_taxon_874 U − 1.99 (0.07) −1.76 (0.15) − 1.88 (0.10) −2.26 (0.11) 0.008 −0.10 0.006
212 Treponema lecithinolyticum U −2.01 (0.08) −1.98 (0.17) − 1.90 (0.12) − 2.18 (0.13) 0.302 −0.10 0.068
213 Prevotella baroniae P −2.04 (0.07) −2.20 (0.15) − 2.03 (0.11) − 1.96 (0.13) 0.490 0.04 0.209
214 Pseudomonas fluorescens P − 2.05 (0.07) − 2.12 (0.15) − 2.07 (0.11) −1.98 (0.13) 0.767 0.03 0.334
215 Shuttleworthia satelles P − 2.08 (0.07) − 2.27 (0.14) − 2.21 (0.10) −1.82 (0.12) 0.016 0.10 <.001
216 Prevotella sp._oral_taxon_306 U −2.08 (0.07) −2.32 (0.14) − 2.21 (0.10) −1.79 (0.13) 0.010 0.10 <.001
217 Porphyromonas sp._oral_taxon_275 N − 2.11 (0.07) −2.09 (0.16) − 2.01 (0.12) − 2.26 (0.12) 0.321 −0.04 0.184
218 Streptococcus sinensis P − 2.14 (0.06) − 1.95 (0.13) − 2.30 (0.08) − 2.05 (0.11) 0.050 0.02 0.517
219 Anaerolineae_[G-1] sp._oral_taxon_439 N − 2.14 (0.08) − 2.47 (0.15) − 2.22 (0.11) −1.85 (0.14) 0.008 0.12 <.001*
220 Bacteroidaceae_[G-1] sp._oral_taxon_272 N − 2.15 (0.07) − 2.48 (0.15) − 2.21 (0.10) −1.87 (0.13) 0.007 0.10 <.001
221 Prevotella micans N − 2.15 (0.07) −2.24 (0.14) − 2.18 (0.10) − 2.08 (0.12) 0.658 0.02 0.452
222 Leptotrichia goodfellowii U − 2.17 (0.07) −1.90 (0.17) −2.14 (0.11) − 2.36 (0.12) 0.080 −0.10 0.008
223 Capnocytophaga sp._oral_taxon_903 N − 2.17 (0.08) −2.15 (0.17) − 2.12 (0.11) − 2.25 (0.13) 0.751 − 0.01 0.731
224 Peptostreptococcaceae_[XI][G-5] [Eubacterium]_saph U − 2.18 (0.08) −2.46 (0.15) − 2.13 (0.12) − 2.08 (0.13) 0.195 0.04 0.229
225 Treponema sp._oral_taxon_237 P − 2.20 (0.08) −1.68 (0.19) −2.21 (0.12) − 2.46 (0.13) 0.003 −0.11 <.001*
226 Fusobacterium sp._oral_taxon_370 U − 2.20 (0.06) −2.25 (0.12) − 2.08 (0.09) − 2.32 (0.10) 0.176 −0.04 0.176
227 Atopobium sp._oral_taxon_199 U − 2.26 (0.07) −2.19 (0.16) − 2.18 (0.11) − 2.40 (0.12) 0.334 −0.02 0.433
228 Prevotella sp._oral_taxon_314 N − 2.28 (0.07) − 2.29 (0.16) − 2.35 (0.11) − 2.18 (0.13) 0.605 0.02 0.519
229 Capnocytophaga sp._oral_taxon_324 U − 2.28 (0.07) −2.43 (0.15) − 2.24 (0.11) − 2.25 (0.12) 0.588 0.03 0.256
230 Haemophilus parahaemolyticus N − 2.29 (0.08) −1.86 (0.18) −2.23 (0.12) − 2.61 (0.11) 0.002 −0.11 <.001*
231 Porphyromonas sp._oral_taxon_278 U − 2.29 (0.07) −2.40 (0.14) − 2.24 (0.11) − 2.30 (0.12) 0.716 0.00 0.977
232 Selenomonas sp._oral_taxon_937 U − 2.35 (0.06) −2.34 (0.12) − 2.46 (0.09) − 2.22 (0.11) 0.203 0.03 0.386
233 Selenomonas dianae N − 2.36 (0.07) − 2.52 (0.14) − 2.27 (0.10) − 2.38 (0.11) 0.367 0.02 0.569
234 Selenomonas sp._oral_taxon_133 U − 2.37 (0.08) − 2.25 (0.18) − 2.40 (0.11) − 2.41 (0.13) 0.719 −0.02 0.396
235 Selenomonas sp._oral_taxon_478 P − 2.49 (0.06) −2.54 (0.13) − 2.46 (0.09) − 2.49 (0.10) 0.882 0.03 0.306
236 Capnocytophaga sp._oral_taxon_332 U − 2.50 (0.07) −2.26 (0.16) − 2.42 (0.11) − 2.72 (0.11) 0.043 −0.10 0.043
237 Megasphaera sp._oral_taxon_123 N − 2.51 (0.08) − 2.06 (0.19) − 2.51 (0.12) − 2.77 (0.13) 0.009 − 0.10 0.002
238 Bradyrhizobium elkanii U − 2.54 (0.08) −2.37 (0.17) − 2.68 (0.11) − 2.44 (0.13) 0.209 −0.00 0.900
239 Prevotella sp._oral_taxon_376 P − 2.54 (0.07) −2.22 (0.17) − 2.49 (0.11) − 2.79 (0.12) 0.015 −0.10 <.001
240 Prevotella sp._oral_taxon_526 P − 2.56 (0.07) −2.59 (0.14) − 2.57 (0.10) − 2.52 (0.12) 0.923 0.01 0.736
241 Selenomonas sp._oral_taxon_442 U − 2.58 (0.05) − 2.78 (0.11) − 2.52 (0.09) − 2.53 (0.09) 0.177 0.10 0.065
242 Leptotrichia sp._oral_taxon_879 U − 2.60 (0.07) − 2.56 (0.16) − 2.62 (0.10) −2.59 (0.11) 0.951 − 0.02 0.597
243 Selenomonas sp._oral_taxon_149 P − 2.61 (0.06) − 2.75 (0.12) − 2.70 (0.09) − 2.42 (0.10) 0.048 0.10 0.004
244 Aggregatibacter sp._oral_taxon_513 U − 2.66 (0.07) − 2.64 (0.14) − 2.52 (0.11) − 2.85 (0.11) 0.107 − 0.03 0.368
245 Treponema vincentii N − 2.67 (0.06) −2.55 (0.13) − 2.60 (0.09) − 2.83 (0.09) 0.140 −0.04 0.125
246 Capnocytophaga sp._oral_taxon_380 N − 2.70 (0.07) −2.65 (0.14) − 2.59 (0.11) − 2.88 (0.11) 0.132 −0.10 0.107
247 Johnsonella sp._oral_taxon_166 U − 2.78 (0.06) −2.96 (0.12) − 2.69 (0.10) − 2.80 (0.11) 0.292 −0.01 0.855
248 Treponema medium P −2.79 (0.06) − 2.85 (0.14) − 2.74 (0.10) −2.81 (0.10) 0.777 0.02 0.579
249 Fretibacterium sp._oral_taxon_358 U − 2.84 (0.07) −2.87 (0.14) − 2.88 (0.10) − 2.77 (0.12) 0.708 0.02 0.494
250 Neisseria pharyngis N − 2.87 (0.06) −2.81 (0.13) − 2.95 (0.09) − 2.80 (0.11) 0.479 0.01 0.760
251 Prevotella sp._oral_taxon_475 N − 2.87 (0.06) −2.81 (0.12) − 2.84 (0.09) − 2.95 (0.09) 0.575 −0.04 0.157
252 Microbacterium flavescens P − 2.89 (0.04) − 2.73 (0.09) − 2.89 (0.06) −2.97 (0.07) 0.151 −0.10 0.051
253 Mitsuokella sp._oral_taxon_521 N − 2.90 (0.06) −2.91 (0.12) − 2.92 (0.08) − 2.87 (0.11) 0.929 0.02 0.603
254 Lactobacillus gasseri N − 2.95 (0.06) −3.08 (0.12) − 3.09 (0.09) −2.70 (0.12) 0.012 0.10 0.002
255 Butyrivibrio sp._oral_taxon_080 P − 2.96 (0.06) −2.85 (0.13) − 2.90 (0.09) −3.10 (0.09) 0.193 −0.10 0.038
256 Fretibacterium sp._oral_taxon_361 P − 2.98 (0.06) − 3.18 (0.10) − 2.97 (0.09) − 2.88 (0.11) 0.207 0.02 0.469
257 Aggregatibacter actinomycetemcomitans P − 3.01 (0.07) −2.97 (0.15) −3.09 (0.10) −2.94 (0.11) 0.575 0.03 0.349
258 Streptococcus sobrinus U − 3.04 (0.06) −3.21 (0.10) − 3.19 (0.09) −2.75 (0.14) 0.005 0.11 <.001*
259 GN02_[G-2] sp._oral_taxon_873 P − 3.06 (0.05) −3.08 (0.12) − 3.03 (0.08) − 3.10 (0.09) 0.851 −0.00 0.927
260 Prevotella multiformis N − 3.08 (0.06) − 3.12 (0.11) − 3.10 (0.09) − 3.05 (0.10) 0.901 0.03 0.359
261 Brevundimonas diminuta N − 3.30 (0.04) − 3.17 (0.09) − 3.35 (0.06) − 3.30 (0.07) 0.232 −0.03 0.306
262 Atopobium sp._oral_taxon_416 P − 3.38 (0.05) − 3.45 (0.09) − 3.44 (0.07) − 3.27 (0.09) 0.202 0.10 0.042
263 Treponema sp._oral_taxon_247 P − 3.45 (0.05) − 3.35 (0.09) − 3.50 (0.07) − 3.44 (0.08) 0.436 − 0.02 0.566
264 Leptothrix sp._oral_taxon_025 P − 3.50 (0.04) −3.37 (0.08) − 3.53 (0.06) − 3.53 (0.06) 0.216 − 0.04 0.221
265 Pyramidobacter piscolens P − 3.53 (0.04) − 3.44 (0.10) − 3.60 (0.06) −3.47 (0.07) 0.251 − 0.01 0.919
266 Sphingomonas sp._oral_taxon_006 P − 3.55 (0.04) −3.49 (0.08) − 3.60 (0.05) − 3.52 (0.06) 0.407 − 0.00 0.989
267 Porphyrobacter tepidarius N −3.58 (0.03) −3.51 (0.08) − 3.65 (0.05) −3.54 (0.06) 0.216 0.01 0.869

Rank order, OTUs are sorted high to low, with most abundant OTU at the top of the table

The CLR OTU is interpreted as a log [2] fold-difference for the given species relative to the overall compositional geometric mean. A mean CLR of 3 indicates a 8-fold [23] higher abundance, and a mean CLR of − 3 indicates a 8-fold lower abundance, relative to the overall compositional geometric mean

SE standard error, Pearson r the Pearson product-moment correlation coefficient

p-values: bolded are significant at alpha 0.05; asterisk are significant at alpha 0.05 after Bonferroni correction

Culture status: N = named; U = unnamed; P = phylotyped

Socransky complex32: R = red; O = orange; P = purple; G = green; Y = yellow; B = blue; −-- = not part of the Socransky classification