. 2019 Nov 14;19:292. doi: 10.1186/s12935-019-1005-9

Table 1.

Analysis of the relation between PFKFB3 and PFKFB4 expression and the overall survival rate in the panel of cancers

Cancer type	Patient number	Source	P value for PFKFB3	P value for PFKFB4
Acute myeloid leukemia	422	GEO ID:GSE37642	0.713	0.704
Adrenocortical carcinoma	79	TCGA ID:ND	0.083^a	0.076^a
B-cell lymphoma	414	GEO ID:GSE10846	0.069^b	0.528
Bladder urothelial carcinoma	224	GEO ID:GSE32894	0.508	0.331
Bladder urothelial carcinoma	408	TCGA ID:BLCA	0.555	0.352
Breast	159	GEO ID:GSE1456	0.405	0.110
Breast	130	GEO ID:GSE69031	0.527	0.913
Breast invasive carcinoma	1096	TCGA ID:BRCA	0.358	0.858
*Cervical squamous cell carcinoma*	*292*	*TCGA ID:CESC*	*0.032*^a	*0.026*^a
Cholangiocarcinoma	36	TCGA ID:CHOL	0.859	0.402
*Colon*	*200*	*GEO ID:GSE17538*	*0.041*^a	0.775
Esophageal adenocarcinomas	70	GEO ID:GSE19417	0.854	0.098^b
Esophageal carcinoma	183	TCGA ID:ESCA	0.814	0.384
Ewing sarcoma	85	GEO ID:GSE63157	0.073^a	0.094^a
Glioblastoma	80	GEO ID:GSE7696	1.000	1.000
Glioblastoma	377	ND ID:ND	0.525	0.286
Glioblastoma	504	ND ID:ND	0.964	0.387
*Glioma*	*490*	*GEO ID:GSE108474*	0.378	*1.2e−09*^a
*Glioma*	*273*	*GEO ID:GSE16011*	0.129	*1.4e−10*^a
*Glioma*	50	*GEO ID:GSE43378*	0.730	*0.028*^a
Glioma pediatric	47	GEO ID:GSE19578	0.092^a	0.625
Intrinsic glioma subtypes	95	GEO ID:GSE43107	0.069^b	0.660
Head neck squamous cell carcinoma	520	TCGA ID:HNSC	0.640	0.875
Kidney renal clear cell carcinoma	533	TCGA ID:KIRC	0.464	0.542
*Kidney renal papillary cell carcinoma*	*290*	*TCGA ID:KIRP*	*0.012*^a	0.064^a
*Liver hepatocellular carcinoma*	*371*	*TCGA ID:LIHC*	0.058^a	*6.6e−05*^a
Lung	106	GEO ID:GSE3141	0.819	0.100^a
Lung adenocarcinoma	515	TCGA ID:LUAD	0.814	0.961
Tumor lymphoma	162	GEO ID:GSE58445	0.315	0.486
Tumor lymphoma	470	GEO ID:GSE31312	0.431	0.555
*Mantle cell lymphoma*	*122*	*GEO ID:GSE93291*	*0.030*^b	0.070^a
Medulloblastoma	612	GEO ID:GSE85217	0.576	0.720
*Melanoma*	*214*	*GEO ID:GSE65904*	0.633	*0.048*^a
Metastatic melanoma	44	GEO ID:GSE19234	0.558	0.394
Myeloma	542	GEO ID:GSE2658	0.078^b	0.514
*Neuroblastoma*	*476*	*GEO ID:GSE45547*	*1.8e−04*^a	*6.2e−04*^b
*Neuroblastoma*	*498*	*GEO ID:GSE62564*	*6.8e−04*^a	*1.6e−06*^b
Neuroblastoma stage IV	27	GEO ID:GSE79910	0.939	0.325
*Neuroblastoma primary*	*283*	*GEO ID:GSE85047*	0.090^a	*3.3e−03*^b
*Neuroblastoma*	*247*	*ND ID:ND*	0.272	*6.1e−03*^b
Neuroblastoma	88	GEO ID:GSE16476	0.398	0.078^b
*Ovarian*	75	*GEO ID:GSE63885*	*3.9e−03*^b	0.941
Ovarian adenocarcinoma	107	GEO ID:GSE26193	0.371	0.302
Pancreatic subtypes	96	ND ID:ND	0.070^a	0.058^a
*Pancreatic adenocarcinoma*	*146*	*TCGA ID:PAAD*	*0.016*^b	0.928
Pancreatic ductal adenocarcinoma	102	GEO ID:GSE21501	0.615	0.598
Skin cutaneous melanoma	468	TCGA ID:SKCM	0.192	0.493
Stomach adenocarcinoma	415	TCGA ID:STAD	0.218	0.738
Thymoma	120	TCGA ID:THYM	0.952	0.113

Bold italic indicates the p value below 0.05

italic indicates the p value between 0.05 and 0.1

ND no data

^aHigh is worse

^bHigh is better