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. 2019 Nov 14;18:160. doi: 10.1186/s12943-019-1095-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Plasma level of circGSK3β is a potential biomarker for ESCC. a The relative levels of circGSK3β in patients with healthy controls, benign lesions, and ESCC. b and c ROC curves showing plasma levels of circGSK3β in ESCC patients (b) and early stages of ESCC patients (c). d and e The comparison of ROC curves of circGSK3β, CEA and the combination of circGSK3β, CEA. f The pre-operative plasma level of circGSK3β and post-operation. g The comparison of percentage of patients with metastasis 10 months after the surgery in high vs. low circGSK3β level. ns., not significant. * P < 0.05; ** P < 0.01; and *** P < 0.001