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. 2019 Nov 13;17:89. doi: 10.1186/s12915-019-0709-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Crosstalk between endoderm cells and cardiac progenitors potentially regulates cardiac lineage commitment. a Volcano plot shows the top ten differentially expressed genes (in colored dots) in cardiac progenitor cells (red dots) versus endoderm cells (blue). Transcription factors are highlighted in orange. GO (b) and KEGG (c) enrichment of differentially expressed genes in cardiac progenitor cells versus endoderm-like cells. The top categories are shown here. Please see Additional file 2 for the full list. d Visualization of VEGF signaling among T05 cells (upper panel) using enriched VEGF ligand-receptor pairs (lower panel). The lines indicate the probabilities of a signal being passed between cells