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. 2019 Oct 29;4(20):18793–18802. doi: 10.1021/acsomega.9b02792

Figure 2.

Figure 2

PE-TB disaggregates the mature Tau fibrils. (A) SDS-PAGE analysis of Tau aggregates treated with varying concentrations of PE-TB ranging from 2 to 40 μM demonstrates a clear decrease in higher-order aggregates. These results indicate the effective role of PDT against higher-order aggregates. The red box indicates the disappearance of higher-order aggregates on SDS-PAGE, which was apparent in the control group. (B, C) Electron microscopy shows long, thick, matured fibrils of Tau, whereas after incubating with PE-TB, Tau exhibits the population of small, broken filaments. This indicated the potency of TB in disintegrating Tau aggregates. (D) ThS fluorescence analysis of PE-TB-treated Tau aggregates. In PDT-treated samples, the fluorescence intensity decreased drastically. Here, 40 μM TB showed the maximum effect in disaggregating the mature aggregates.