Figure 4.

Modulation of the cytoskeleton network by PE-TB. The cells were treated with various concentrations of TB. At lower concentration, TB (0.5 μM) showed high expression of tubulin with increased neurite outgrowth, whereas high TB concentration (5 μM) was found to be toxic to cells. PE-TB also showed extended neurite outgrowth at lower concentration, whereas 5 μM PE-TB was cytotoxic. The fluorescent image of a tubulin-stained single neuronal cell suggested that distribution of tubulin was prominently in neurite outgrowths and Tau was distributed in the cell soma.