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. 2019 Oct 29;4(20):18793–18802. doi: 10.1021/acsomega.9b02792

Figure 5.

Figure 5

Effect of TB and PE-TB on behavior of transgenic Drosophila. (A) Transgenic flies were exposed to TB and PE-TB for various time points at different stages of life cycle to study their effect in restoring memory deficit, locomotory dysfunction, and viability. (B) Results suggest the effect of various concentrations of TB and PE-TB on feeding behavior of flies. PE-TB was found to be more potent than non-photo-excited TB. (C) E14 Tau flies were exposed to various concentrations of TB to analyze changes in olfactory sensation by avoiding the bad odor of quinine. The 5 μM concentration of PE-TB demonstrated appreciable potency in restoring the olfaction. (D) Negative geotaxis assay was performed to examine the effect of TB on locomotion of flies. The bell-shaped graph indicated 5 μM PE-TB to be effective in rescuing the locomotory system of E14 Tau Drosophila. (E) Data indicates 5 μM TB to have appreciable effect on the survival rate of transgenic flies. The significance was calculated using Student’s t-test in SigmaPlot 10.0, where *p < 0.05, **p < 0.001, and ***p < 0.0001, the statistical difference between control and treated groups before photoexcitation, and #p < 0.05, ##p < 0.001, and ###p < 0.0001, the statistical difference between control and treated groups after photoexcitation.