Figure 4.

Intrinsic properties of cerebellar GABAergic neurons. (A) Electroresponsiveness of a Golgi cell. The neuron shows low-frequency pacemaking activity and, upon depolarizing current injection, high-frequency spike discharge. Spike discharges are followed by an afterhyperpolarization and a silent pause. Upon hyperpolarizing current injection, the Golgi cell shows sagging inward rectification, followed by a post-inhibitory rebound. Adapted from Forti et al. (2006). (B) Whole-cell current-clamp recording in rat cerebellar slices demonstrated that the spontaneously inactive LC was reversibly excited by serotonin (1 μM). Below, summary of the effect of serotonin on the firing frequency of a LC. Adapted from Dieudonné and Dumoulin (2000). (C) Cell-attached patch-clamp recording from a ML interneuron under control conditions and during the block of inhibition. Below, autocorrelation of action potential trains from the corresponding recordings. Note that the block of inhibition causes a marked increase in the regularity of firing. Adapted from Hausser and Clark (1997).