Table 2.
Crude and multivariable adjusted odds ratio (OR) for large final infarct size.
| OR | 95% CI | p value | |
|---|---|---|---|
| Univariate analyses | |||
| High dsDNA on day 11 | 2.9 | 1.5–5.4 | 0.001 |
| Age, per year | 0.99 | 0.96–1.02 | 0.400 |
| Male gender | 3.3 | 1.2–8.7 | 0.017 |
| Time, symptoms to PCI (ln), per SD | 1.2 | 0.9–1.6 | 0.275 |
| Anterior MI | 8.2 | 4.0–16.8 | <0.001 |
| Ischemic postconditioning | 0.4 | 0.2–0.8 | 0.007 |
| Total cholesterol (mmol/l), admission | 0.94 | 0.72–1.23 | 0.668 |
| Peak CRP (ln), per SD | 3.6 | 2.3–5.6 | <0.001 |
| CRP after 4 months (ln), per SD | 1.2 | 0.9–1.6 | 0.163 |
| Peak troponin T (ln), per SD | 21.3 | 9.3–48.9 | <0.001 |
| Multivariable analyses | |||
| Model 1 | |||
| High dsDNA on day 11 | 2.3 | 1.1–4.6 | 0.021 |
| Male gender | 2.7 | 0.9–7.9 | 0.078 |
| Time, symptoms to PCI (ln), per SD | 1.4 | 0.96–1.99 | 0.082 |
| Anterior MI | 7.3 | 3.4–15.6 | <0.001 |
| Ischemic postconditioning | 0.4 | 0.2–0.8 | 0.007 |
| Model 2 | |||
| High dsDNA on day 11 | 1.4 | 0.6–3.1 | 0.458 |
| Male gender | 4.1 | 1.1–15.3 | 0.037 |
| Time, symptoms to PCI (ln), per SD | 1.4 | 0.9–2.2 | 0.095 |
| Anterior MI | 5.5 | 2.4–12.8 | <0.001 |
| Ischemic postconditioning | 0.3 | 0.1–0.6 | 0.003 |
| Peak CRP (ln), per SD | 3.1 | 1.9–5.1 | <0.001 |
| Model 3 | |||
| High dsDNA on day 11 | 0.7 | 0.3–1.8 | 0.456 |
| Male gender | 1.5 | 0.4–6.1 | 0.535 |
| Time, symptoms to PCI (ln), per SD | 1.1 | 0.7–1.7 | 0.744 |
| Anterior MI | 3.1 | 1.3–7.7 | 0.014 |
| Ischemic postconditioning | 0.3 | 0.1–0.8 | 0.012 |
| Peak troponin T (ln), per SD | 16.6 | 6.5–42.2 | <0.001 |
Large final infarct size is defined as >75th percentile (>22.8% of LV volume) at CMR 4 months after the STEMI. 1>median (366 ng/ml). CI: confidence interval. CRP: C-reactive protein. dsDNA: double-stranded deoxyribonucleic acid. ln: natural logarithm. MI: myocardial infarction. PCI: percutaneous coronary intervention. SD: standard deviation.